K63-linked polyubiquitin modification-dependent protein binding
metal ion binding
polyubiquitin modification-dependent protein binding
Cellular component
recycling endosome
endosome
Golgi membrane
nucleoplasm
autophagosome
trans-Golgi network
perinuclear region of cytoplasm
nucleus
Golgi apparatus
cytoplasm
cytosol
recycling endosome membrane
cytoplasmic vesicle
Biological process
Golgi organization
cell death
negative regulation of I-kappaB kinase/NF-kappaB signaling
autophagy
G2/M transition of mitotic cell cycle
defense response to Gram-negative bacterium
negative regulation of receptor recycling
vesicle-mediated transport
regulation of I-kappaB kinase/NF-kappaB signaling
signal transduction
Golgi to plasma membrane protein transport
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
positive regulation of xenophagy
positive regulation of autophagy
Unfolded Protein Response
Golgi ribbon formation
immune system process
innate immune response
protein localization to Golgi apparatus
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10133
71648
Ensembl
ENSG00000123240
ENSMUSG00000026672
UniProt
Q96CV9
Q8K3K8
RefSeq (mRNA)
NM_001008211 NM_001008212 NM_001008213 NM_021980
NM_181848 NM_001356487
RefSeq (protein)
NP_001008212 NP_001008213 NP_001008214 NP_068815
NP_862896 NP_001343416
Location (UCSC)
Chr 10: 13.1 – 13.14 Mb
Chr 2: 5.03 – 5.07 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Optineurin is a protein that in humans is encoded by the OPTN gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000123240 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026672 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Rezaie T, Child A, Hitchings R, Brice G, Miller L, Coca-Prados M, Héon E, Krupin T, Ritch R, Kreutzer D, Crick RP, Sarfarazi M (February 2002). "Adult-onset primary open-angle glaucoma caused by mutations in optineurin". Science. 295 (5557): 1077–9. Bibcode:2002Sci...295.1077R. doi:10.1126/science.1066901. PMID 11834836. S2CID 23635499.
^Li Y, Kang J, Horwitz MS (March 1998). "Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains". Molecular and Cellular Biology. 18 (3): 1601–10. doi:10.1128/mcb.18.3.1601. PMC 108875. PMID 9488477.
Optineurin is a protein that in humans is encoded by the OPTN gene. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play...
Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin". PLOS...
through the attachment of Ubiquitin and finally the phosphorylating protein optineurin binds to them. This tags them for special cell organelles, the autophagosomes...
OPTN may refer to: Optineurin Organ Procurement and Transplantation Network, operated by the United Network for Organ Sharing, which facilitates organ...
to do any physical activity due to the atrophy of their muscles. The optineurin gene (OPTN) and its mutation are known to be involved in ALS. When the...
Suzanne R (eds.). "Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons". eLife. 9: e50260. doi:10.7554/eLife.50260...
et al. (2007). "SNPs and interaction analyses of noelin 2, myocilin, and optineurin genes in Japanese patients with open-angle glaucoma". Invest. Ophthalmol...
to MY09B on chromosome 19p13.1. RAB8A has been shown to interact with Optineurin and MAP4K2. GRCh38: Ensembl release 89: ENSG00000167461 – Ensembl, May...
protein production. This results in no phosphorylation of the p62 and optineurin proteins. As a result, motor neurons can no longer produce a functional...
526-537, doi:10.1038/s41556-021-00672-3 (2021). Du, W. et al. Loss of optineurin drives cancer immune evasion via palmitoylation-dependent IFNGR1 lysosomal...
counter measures. The kinase Tbk1 was identified as important for mediating optineurin based xenophagy to remove the bacteria from the infected cells. Using...