Oncofetal antigens are proteins which are typically present only during fetal development but are found in adults with certain kinds of cancer. These proteins are often measurable in the blood of individuals with cancer and may be used to both diagnose and follow treatment of the tumors. One example of an oncofetal antigen is alpha-fetoprotein, which is produced by hepatocellular carcinoma and some germ cell tumors. Another example is carcinoembryonic antigen, which is elevated in people with colon cancer and other tumors. Other oncofetal antigens are trophoblast glycoprotein precursor[1] and immature laminin receptor protein (also known as oncofetal antigen protein). Oncofetal antigens are promising targets for vaccination against several types of cancers.
^37 kiloDalton oncofetal antigen protein and immature laminin receptor protein are identical, universal T-cell inducing immunogens on primary rodent and human cancers. Anticancer Res. 1999 Nov-Dec;19(6C):5535-42. PMID 10697612
Oncofetalantigens are proteins which are typically present only during fetal development but are found in adults with certain kinds of cancer. These proteins...
melanoma cells. Oncofetalantigens are another important class of tumor antigens. Examples are alphafetoprotein (AFP) and carcinoembryonic antigen (CEA). These...
expression. Oncofetalantigens are tumor-associated antigens expressed by embryonic cells and by tumors. Examples of oncofetalantigens are AFP (α-fetoprotein)...
containing eight leucine-rich repeats. 5T4 is often referred to as an oncofetalantigen due to its expression in foetal trophoblast (where it was first discovered)...
oncofetalantigens and monoclonal antibodies, due to disadvantages such as most of them lacking organ specificity. Carbohydrates consists of antigens...
2011). "Delineation of a cellular hierarchy in lung cancer reveals an oncofetalantigen expressed on tumor-initiating cells". Cancer Research. 71 (12): 4236–46...
(2003-12-15). "Induction of cytotoxic T-cell responses against the oncofetalantigen-immature laminin receptor for the treatment of hematologic malignancies"...
more than half of gastric cancers, leading to it appearing to be an oncofetalantigen. Transcript variants utilizing alternative polyadenylation signals...
infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetalantigen and receptor for Wnt5a". Proceedings of the National Academy of Sciences...
In addition, many of acquired nonself surfaces e.g. carcinoembryonic/oncofetal type neoantigens carrying "internal danger source"/"self turned nonself"...
A similar correlation has been found in colorectal tumors. GPC3 is an oncofetal protein in both liver and intestine, as GPC3 is typically only expressed...
malignancy and resistance to therapy by complexing, and hence, stabilizing, oncofetal proteins and products and transporting them into intracellular sites,...
malignancy and resistance to therapy by complexing, and hence, stabilizing, oncofetal proteins and products and transporting them into intracellular sites,...
instead of antibodies, such as the malaria VAR2CSA protein, which binds to oncofetal chondroitin sulfate on the surface of CTCs. CTCs may also be retrieved...
Fab moiety targeting the 5T4 antigen fused with a genetically engineered superantigen moiety. The 5T4 antigen is an oncofetal glycoprotein that is upregulated...
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