Opsin-5, also known as G-protein coupled receptor 136 or neuropsin is a protein that in humans is encoded by the OPN5 gene. Opsin-5 is a member of the opsin subfamily of the G protein-coupled receptors.[5][6][7] It is a photoreceptor protein sensitive to ultraviolet (UV) light. The OPN5 gene was discovered in mouse and human genomes and its mRNA expression was also found in neural tissues. Neuropsin is bistable at 0 °C and activates a UV-sensitive, heterotrimeric G protein Gi-mediated pathway in mammalian and avian tissues.[8][9]
^ abcGRCh38: Ensembl release 89: ENSG00000124818 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000043972 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Letters. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098. S2CID 11563502.
^"Entrez Gene: OPN5 opsin 5".
^Kojima D, Mori S, Torii M, Wada A, Morishita R, Fukada Y (2011). "UV-sensitive photoreceptor protein OPN5 in humans and mice". PLOS ONE. 6 (10): e26388. Bibcode:2011PLoSO...626388K. doi:10.1371/journal.pone.0026388. PMC 3197025. PMID 22043319.
^Yamashita T, Ohuchi H, Tomonari S, Ikeda K, Sakai K, Shichida Y (December 2010). "Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein". Proceedings of the National Academy of Sciences of the United States of America. 107 (51): 22084–22089. Bibcode:2010PNAS..10722084Y. doi:10.1073/pnas.1012498107. PMC 3009823. PMID 21135214.
receptor 136 or neuropsin is a protein that in humans is encoded by the OPN5 gene. Opsin-5 is a member of the opsin subfamily of the G protein-coupled...
vision. They couple to Gi-proteins. In humans, Neuropsin is encoded by the OPN5 gene. In the human retina, its function is unknown. In the mouse, it photo-entrains...
neuropsin may refer to: Kallikrein 8, an enzyme class OPN5, a protein that in humans is encoded by the OPN5 gene This disambiguation page lists articles associated...
Gelder's lab found that OPN5 was sufficient in entraining the circadian rhythms of mice cornea ex-vivo, ascertaining the function of OPN5, which until then...
MT, Reed RR, Lang RA, Yau KW, Van Gelder RN (20 Oct 2015). ""Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina...
optical network within the brain[citation needed], mediated by neuropsin (OPN5). This self-regulating cycle of photon-mediated events in the neocortex involves...