Nucleolar phosphoprotein p130 information

NOLC1
Identifiers
Aliases	NOLC1, NOPP130, NOPP140, NS5ATP13, P130, Nucleolar phosphoprotein p130, nucleolar and coiled-body phosphoprotein 1, Srp40
External IDs	OMIM: 602394; MGI: 1918019; HomoloGene: 68818; GeneCards: NOLC1; OMA:NOLC1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	102,163,871 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	46,073,969 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; germinal epithelium; ; parietal pleura; ; endothelial cell; ; pancreatic epithelial cell; ; visceral pleura; ; sperm; ; tibia; ; amniotic fluid;
	Top expressed in
	morula; ; primitive streak; ; somite; ; yolk sac; ; maxillary prominence; ; abdominal wall; ; hair follicle; ; Paneth cell; ; dermis; ; superior cervical ganglion;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; ATP binding; RNA binding; RNA polymerase I core binding; protein heterodimerization activity; DNA binding; DNA-binding transcription factor activity; transcription factor binding; nuclear localization sequence binding; protein domain specific binding; box C/D RNA binding; box H/ACA snoRNA binding; box C/D snoRNP complex binding; box H/ACA snoRNP complex binding;
Cellular component	cytoplasm; Cajal body; nucleus; nucleoplasm; nucleolus; fibrillar center; box C/D RNP complex; box H/ACA snoRNP complex;
Biological process	rRNA processing; cell cycle; nucleolus organization; regulation of translation; neural crest formation; neural crest cell development; mitotic cell cycle; response to osmotic stress; positive regulation of cell population proliferation; box H/ACA RNA metabolic process; regulation of protein import into nucleus; positive regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	9221
	70769
	ENSG00000166197
	ENSMUSG00000015176
	Q14978
	E9Q5C9
	NM_001284388; NM_001284389; NM_004741
	NM_001039351; NM_001039352; NM_001039353; NM_053086
	NP_001271317; NP_001271318; NP_004732
	NP_001034440; NP_001034441; NP_001034442; NP_444316
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleolar phosphoprotein p130 is a protein that in humans is encoded by the NOLC1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166197 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015176 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pai CY, Chen HK, Sheu HL, Yeh NH (Oct 1995). "Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis". J Cell Sci. 108. ( Pt 5) (5): 1911–20. doi:10.1242/jcs.108.5.1911. PMID 7657714.
^ Chen HK, Pai CY, Huang JY, Yeh NH (Jan 2000). "Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization". Mol Cell Biol. 19 (12): 8536–46. doi:10.1128/MCB.19.12.8536. PMC 84972. PMID 10567578.
^ "Entrez Gene: NOLC1 nucleolar and coiled-body phosphoprotein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166197 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015176 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7657714-5] Pai CY, Chen HK, Sheu HL, Yeh NH (Oct 1995). "Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis". J Cell Sci. 108. ( Pt 5) (5): 1911–20. doi:10.1242/jcs.108.5.1911. PMID 7657714.

[pmid10567578-6] Chen HK, Pai CY, Huang JY, Yeh NH (Jan 2000). "Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization". Mol Cell Biol. 19 (12): 8536–46. doi:10.1128/MCB.19.12.8536. PMC 84972. PMID 10567578.

[entrez-7] "Entrez Gene: NOLC1 nucleolar and coiled-body phosphoprotein 1".

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