Nucleobindin 2 information

NUCB2
Identifiers
Aliases	NUCB2, HEL-S-109, NEFA, nucleobindin 2
External IDs	OMIM: 608020; MGI: 1858179; HomoloGene: 3676; GeneCards: NUCB2; OMA:NUCB2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	17,349,974 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	116,139,819 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; tendon of biceps brachii; ; bronchial epithelial cell; ; olfactory zone of nasal mucosa; ; seminal vesicula; ; bone marrow cells; ; corpus epididymis; ; Achilles tendon; ; trabecular bone; ; body of pancreas;
	Top expressed in
	seminal vesicula; ; lacrimal gland; ; salivary gland; ; submandibular gland; ; lobe of prostate; ; parotid gland; ; islet of Langerhans; ; saccule; ; olfactory epithelium; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; calcium ion binding; protein binding; metal ion binding;
Cellular component	cytoplasm; extracellular region; cytosol; plasma membrane; Golgi apparatus; extracellular exosome; nuclear envelope; endoplasmic reticulum; membrane; nucleus; endoplasmic reticulum-Golgi intermediate compartment; extracellular space; nuclear outer membrane;
Biological process	negative regulation of appetite;
	Sources:Amigo / QuickGO
Orthologs
	4925
	53322
	ENSG00000070081
	ENSMUSG00000030659
	P80303
	P81117
NM_005013; NM_001330227; NM_001352661; NM_001352662; NM_001352663;
	NM_001352664; NM_001352665; NM_001352666; NM_001352667; NM_001352668; NM_001352669; NM_001352670; NM_001352671; NM_001352672
	NM_001130479; NM_016773; NM_001360375
NP_001317156; NP_005004; NP_001339590; NP_001339591; NP_001339592;
	NP_001339593; NP_001339594; NP_001339595; NP_001339596; NP_001339597; NP_001339598; NP_001339599; NP_001339600; NP_001339601
	NP_001123951; NP_001347304
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleobindin-2 is a protein that when found in humans is encoded by the NUCB2 gene.^[5]^[6]

Nucleobindin-2 is a calcium-binding EF-hand protein.[supplied by OMIM]^[6]

NUCB2 is protein precursor of nesfatin-1

In the study of the evolution of nervous systems, NUCB2 together with SMIM20 have been found to have deep homology across all lineages that preceded creatures with central nervous systems, bilaterians, cnidarians, ctenophores, and sponges as well as in choanoflagellates.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070081 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030659 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Barnikol-Watanabe S, Gross NA, Götz H, Henkel T, Karabinos A, Kratzin H, et al. (August 1994). "Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein". Biological Chemistry Hoppe-Seyler. 375 (8): 497–512. doi:10.1515/bchm3.1994.375.8.497. PMID 7811391.
^ ^a ^b "Entrez Gene: NUCB2 nucleobindin 2".
^ Yañez-Guerra LA, Thiel D, Jékely G (April 2022). O'Connell M (ed.). "Premetazoan Origin of Neuropeptide Signaling". Molecular Biology and Evolution. 39 (4): msac051. doi:10.1093/molbev/msac051. PMC 9004410. PMID 35277960.
^ Callier V (2022-06-03). "Brain-Signal Proteins Evolved Before Animals Did". Quanta Magazine. Retrieved 2022-06-03.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000070081 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030659 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7811391-5] Barnikol-Watanabe S, Gross NA, Götz H, Henkel T, Karabinos A, Kratzin H, et al. (August 1994). "Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein". Biological Chemistry Hoppe-Seyler. 375 (8): 497–512. doi:10.1515/bchm3.1994.375.8.497. PMID 7811391.

[entrez-6] "Entrez Gene: NUCB2 nucleobindin 2".

[7] Yañez-Guerra LA, Thiel D, Jékely G (April 2022). O'Connell M (ed.). "Premetazoan Origin of Neuropeptide Signaling". Molecular Biology and Evolution. 39 (4): msac051. doi:10.1093/molbev/msac051. PMC 9004410. PMID 35277960.

[8] Callier V (2022-06-03). "Brain-Signal Proteins Evolved Before Animals Did". Quanta Magazine. Retrieved 2022-06-03.

Nucleobindin 2 information

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