Global InformationNociceptive trigeminal inhibition tension suppression system information
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The Nociceptive trigeminal inhibition tension suppression system (abbreviated to NTI-TSS, or NTI-tension suppression system),[1] is a type of occlusal splint that is claimed to prevent headache and migraine by reducing sleep bruxism (night-time tooth clenching and grinding). Sleep bruxism is purported to lead to a hyperactivity of the trigeminal nerve, often triggering typical migraine events. The hyperactivity of trigeminal neurons during trigemino-nociceptive stimulation is a proposed cause of migraine and is correlated with imaging of migraine sufferers.[2] The objective of the NTI-TSS is to relax the muscles involved in clenching and bruxing, thus supposedly diminishing the chances for migraines and tension headaches to develop through the reduction in nociceptive stimulation normally caused by parafunctional activity. It is sometimes used for temporomandibular joint dysfunction (TMD).
The NTI-TSS is a small transparent plastic device which is, in its most widely used form, worn over the front four teeth, of either arch, at night, and intended to prevent contact of the canines and molars. It is normally fitted by a dentist trained in the technique, and is constructed by a dental laboratory.[3]
However in FDA trials the Nociceptive Trigeminal Inhibition Tension Suppression System (NTI-tss) had been proven to provide a 77% reduction of migraine events in 82% of subjects tested.[4][5] Practical Neurology Oct. 2005[6] The origin of the pain must be determined in each individual, and each contributory factor must be addressed. Most migraine sufferers have a combination of two or more of the following: a) vascular pain (pain originating in the arteries of the scalp),[7] b) muscular pain (pain originating from the jaw and neck muscles),[8][9][10][11] c) pain or abnormal sensitivity of the skin of the scalp (known as cutaneous allodynia),[12] and hypersensitivity of the brain to incoming pain messages[13]
- ^ Stapelmann, Henrike; Türp, Jens C. (2008). "The NTI-TSS device for the therapy of bruxism, temporomandibular disorders, and headache – Where do we stand? A qualitative systematic review of the literature". BMC Oral Health. 8: 22. doi:10.1186/1472-6831-8-22. PMC 2583977. PMID 18662411.
- ^ Burstein, R., Noseda, R., & Borsook, D. (April 29, 2015). Migraine: Multiple Processes, Complex Pathophysiology. Journal of Neuroscience, 35(17), 6619-6629.
- ^ https://nationaldentex.com/products/headache-therapy/nti-tss-plus
- ^ Practical Neurology Oct. 2005
- ^ Blumenfeld, Andrew M.; Boyd, James P. (April 3, 2004). "Adjunctive treatment of chronic migraine using an oral dental device: overview and results of a randomized placebo-controlled crossover study". NLM. 22 (1): 72. doi:10.1186/s12883-022-02591-8. ISSN 1471-2377. PMC 8895632. PMID 35246048.
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- ^ Shevel E (2011). "The Extracranial Vascular Theory of Migraine – A Great Story Confirmed by the Facts". Headache. 51 (3): 409–417. doi:10.1111/j.1526-4610.2011.01844.x. PMID 21352215. S2CID 6939786.
- ^ Tfelt-Hansen P; Lous I; Olesen J. (1981). "Prevalence and significance of muscle tenderness during common migraine attacks". Headache. 21 (2): 49–54. doi:10.1111/j.1526-4610.1981.hed2102049.x. PMID 7239900. S2CID 42206728.
- ^ Jensen K, Bulow P, Hansen H (1985). "Experimental toothclenching in common migraine". Cephalalgia. 5 (4): 245–251. doi:10.1046/j.1468-2982.1985.0504245.x. PMID 4084979. S2CID 23648142.
- ^ Fernández-de-Las-Peñas C; Cuadrado ML; Arendt-Nielsen L; Pareja JA. (2008). "Side-to-side differences in pressure pain thresholds and pericranial muscle tenderness in strictly unilateral migraine". Eur J Neurol. 15 (2): 162–8. doi:10.1111/j.1468-1331.2007.02020.x. PMID 18093151. S2CID 8537431.
- ^ Fernández-de-Las-Peñas C, Cuadrado ML, Pareja JA (2006). "Myofascial trigger points, neck mobility and forward head posture in unilateral migraine". Cephalalgia. 26 (9): 1061–70. doi:10.1111/j.1468-2982.2006.01162.x. PMID 16919056. S2CID 12915013.
- ^ Burstein R, Cutrer MF, Yarnitsky D (2000). "The development of cutaneous allodynia during a migraine attack". Brain. 123: 1703–9. doi:10.1093/brain/123.8.1703. PMID 10908199.
- ^ Strassman AM, Raymond SA, Burstein R (1996). "Sensitization of meningeal sensory neurons and the origin of headaches". Nature. 384 (6609): 560–4. Bibcode:1996Natur.384..560S. doi:10.1038/384560a0. PMID 8955268. S2CID 4323574.