Neural facilitation, also known as paired-pulse facilitation (PPF), is a phenomenon in neuroscience in which postsynaptic potentials (PSPs) (EPPs, EPSPs or IPSPs) evoked by an impulse are increased when that impulse closely follows a prior impulse. PPF is thus a form of short-term synaptic plasticity. The mechanisms underlying neural facilitation are exclusively pre-synaptic; broadly speaking, PPF arises due to increased presynaptic Ca2+ concentration leading to a greater release of neurotransmitter-containing synaptic vesicles.[1] Neural facilitation may be involved in several neuronal tasks, including simple learning, information processing,[2] and sound-source localization.[3]
^Zucker, Robert S.; Regehr, Wade G. (2002). "Short-Term Synaptic Plasticity". Annu. Rev. Physiol. 64: 355–405. doi:10.1146/annurev.physiol.64.092501.114547. PMID 11826273. S2CID 7980969.
^Fortune, Eric S.; Rose, Gary J. (2001). "Short-term synaptic plasticity as a temporal filter". Trends in Neurosciences. 24 (7): 381–5. doi:10.1016/s0166-2236(00)01835-x. PMID 11410267. S2CID 14642561.
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