Neridronic acid information

Neridronic acid
Clinical data
ATC code	none;
Identifiers
	IUPAC name (6-Amino-1-hydroxyhexane-1,1-diyl)bis(phosphonic acid);
CAS Number	79778-41-9 ;
PubChem CID	71237;
ChemSpider	64372 ;
UNII	8U27U3RIN4;
CompTox Dashboard (EPA)	DTXSID40868545 ;
ECHA InfoCard	100.163.818
Chemical and physical data
Formula	C6H17NO7P2
Molar mass	277.150 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(CCC(O)(P(=O)(O)O)P(=O)(O)O)CCN;
	InChI InChI=1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14) ; Key:PUUSSSIBPPTKTP-UHFFFAOYSA-N ;
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Neridronic acid (INN; the anion is called neridronate) is a bisphosphonate. In Italy it is used to treat Osteogenesis imperfecta and Paget's disease of bone.^[1]

A 2013 clinical trial suggests CRPS Type I (Complex regional pain syndrome) responds to treatment with intravenous neridronate.^[2]

^ Gatti D, Viapiana O, Idolazzi L, Fracassi E, Adami S (2009). "Neridronic acid for the treatment of bone metabolic diseases". Expert Opin Drug Metab Toxicol. 5 (10): 1305–11. doi:10.1517/17425250903029190. PMID 19761412. S2CID 22274296.
^ Varenna M, Adami S, Rossini M, et al. (March 2013). "Treatment of complex regional pain syndrome type I with neridronate: a randomized, double-blind, placebo-controlled study". Rheumatology. 52 (3): 534–42. doi:10.1093/rheumatology/kes312. PMID 23204550.

[1] Gatti D, Viapiana O, Idolazzi L, Fracassi E, Adami S (2009). "Neridronic acid for the treatment of bone metabolic diseases". Expert Opin Drug Metab Toxicol. 5 (10): 1305–11. doi:10.1517/17425250903029190. PMID 19761412. S2CID 22274296.

[Varenna_2013_534–42-2] Varenna M, Adami S, Rossini M, et al. (March 2013). "Treatment of complex regional pain syndrome type I with neridronate: a randomized, double-blind, placebo-controlled study". Rheumatology. 52 (3): 534–42. doi:10.1093/rheumatology/kes312. PMID 23204550.

Clinical data

ATC code	none
Identifiers
IUPAC name (6-Amino-1-hydroxyhexane-1,1-diyl)bis(phosphonic acid)
CAS Number	79778-41-9^Y
PubChem CID	71237
ChemSpider	64372^N
UNII	8U27U3RIN4
CompTox Dashboard (EPA)	DTXSID40868545
ECHA InfoCard	100.163.818
Chemical and physical data
Formula	C₆H₁₇NO₇P₂
Molar mass	277.150 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C(CCC(O)(P(=O)(O)O)P(=O)(O)O)CCN
InChI InChI=1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)^N Key:PUUSSSIBPPTKTP-UHFFFAOYSA-N^N
^NY (what is this?) (verify)