Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Neoxaline is a bio-active Aspergillus japonicus isolate. It is an antimitotic agent and shows weak inhibitory activity of blood platelet aggregation. It stimulates the central nervous system.[1][2] It has been synthesized through the "highly stereoselective introduction of a reverse prenyl group to create a quaternary carbon stereocenter using (−)-3a-hydroxyfuroindoline as a building block, construction of the indoline spiroaminal via cautious stepwise oxidations with cyclizations from the indoline, assembly of (Z)-dehydrohistidine, and photoisomerization of unnatural (Z)-neoxaline to the natural (E)-neoxaline."[3]
^Neoxaline an antimiotic agent
^Hirano, A.; Iwai, Y.; Masuma, R.; Tei, K.; Omura, S. (August 1979). "Neoxaline, a new alkaloid produced by Aspergillus japonicus. Production, isolation and properties". The Journal of Antibiotics. 32 (8): 781–785. doi:10.7164/antibiotics.32.781. PMID 500498.
^Ideguchi, Tetsuya; Yamada, Takeshi; Shirahata, Tatsuya; Hirose, Tomoyasu; Sugawara, Akihiro; Kobayashi, Yoshinori; O̅mura, Satoshi; Sunazuka, Toshiaki (19 August 2013). "Asymmetric Total Synthesis of Neoxaline". Journal of the American Chemical Society. 135 (34): 12568–12571. doi:10.1021/ja406657v. PMID 23957424.
Neoxaline is a bio-active Aspergillus japonicus isolate. It is an antimitotic agent and shows weak inhibitory activity of blood platelet aggregation....
Phipps, Richard K.; Frydenvang, Karla; Larsen, Thomas O. (2006). "Epi-Neoxaline, a chemotaxonomic marker for Penicillium tulipae". Biochemical Systematics...
has been isolated from Thai coffee beans. It has been shown to produce neoxaline, secalonic acid D and F, and aculeacins. The genome of A. aculeatinus...
vincristine, podophyllotoxin, griseofulvin, aurantiamine, oxaline, and neoxaline are produced by fungi. Many fungi have been used as folk medicines around...