Global InformationNaphthoate synthase information
| 1,4-dihydroxy-2-naphthoyl-CoA synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 1,4-Dihydroxy-2-naphthoyl-CoA synthase hexamer, Mycobacterium tuberculosis | |||||||||
| Identifiers | |||||||||
| EC no. | 4.1.3.36 | ||||||||
| CAS no. | 72506-71-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme 1,4-dihydroxy-2-naphthoyl-CoA synthase (EC 4.1.3.36) catalyzes the sixth step in the biosynthesis of phylloquinone and menaquinone, the two forms of vitamin K. In E. coli, 1,4-dihydroxy-2-naphthoyl-CoA synthase, formerly known as naphthoate synthase, is encoded by menB and uses O-succinylbenzoyl-CoA as a substrate and converts it to 1,4-dihydroxy-2-naphthoyl-CoA.[1]
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