adenosine 5'-(hexahydrogen pentaphosphate) catabolic process
diphosphoinositol polyphosphate metabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
11165
56409
Ensembl
ENSG00000272325
ENSMUSG00000024213
UniProt
O95989
Q9JI46
RefSeq (mRNA)
NM_006703
NM_001291046 NM_019837
RefSeq (protein)
NP_006694
NP_001277975 NP_062811
Location (UCSC)
Chr 6: 34.28 – 34.39 Mb
Chr 17: 27.8 – 27.84 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Diphosphoinositol polyphosphate phosphohydrolase 1 is an enzyme that in humans is encoded by the NUDT3 gene.[5][6]
NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998).[supplied by OMIM][6]
^ abcGRCh38: Ensembl release 89: ENSG00000272325 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024213 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (Jan 1999). "A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase". EMBO J. 17 (22): 6599–607. doi:10.1093/emboj/17.22.6599. PMC 1171006. PMID 9822604.
phosphohydrolase 1 is an enzyme that in humans is encoded by the NUDT3 gene. NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act...