dentate gyrus of hippocampal formation granule cell
nucleus of stria terminalis
anterior horn of spinal cord
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
peptide binding
zinc ion binding
peptidase activity
metalloaminopeptidase activity
metallopeptidase activity
hydrolase activity
metal ion binding
aminopeptidase activity
Cellular component
extracellular exosome
nucleus
cytosol
cytoplasm
Biological process
protein polyubiquitination
cellular response to hypoxia
positive regulation of protein targeting to mitochondrion
peptide catabolic process
proteolysis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9520
19155
Ensembl
ENSG00000141279
ENSMUSG00000001441
UniProt
P55786
Q11011
RefSeq (mRNA)
NM_006310 NM_001330257
NM_008942
RefSeq (protein)
NP_001317186 NP_006301
NP_032968
Location (UCSC)
Chr 17: 47.52 – 47.62 Mb
Chr 11: 97.1 – 97.17 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Puromycin-sensitive amino peptidase also known as cytosol alanyl aminopeptidase or alanine aminopeptidase (AAP) (EC 3.4.11.14) is an enzyme that in humans is encoded by the NPEPPS gene.[5][6][7] It is used as a biomarker to detect damage to the kidneys, and that may be used to help diagnose certain kidney disorders. It is found at high levels in the urine when there are kidney problems.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000141279 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000001441 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tobler AR, Constam DB, Schmitt-Gräff A, Malipiero U, Schlapbach R, Fontana A (March 1997). "Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons". Journal of Neurochemistry. 68 (3): 889–97. doi:10.1046/j.1471-4159.1997.68030889.x. PMID 9048733. S2CID 30408265.
^Thompson MW, Tobler A, Fontana A, Hersh LB (May 1999). "Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase". Biochemical and Biophysical Research Communications. 258 (2): 234–40. doi:10.1006/bbrc.1999.0604. PMID 10329370.
of NPEPPS function exacerbates neurodegeneration. The NPEPPS gene is located at chromosome 17q21, consisting of 25 exons and spanning 40 kb. NPEPPS is...