NOXRED1 information

NOXRED1
Identifiers
Aliases	NOXRED1, C14orf148, NADP-dependent oxidoreductase domain containing 1, NADP dependent oxidoreductase domain containing 1
External IDs	MGI: 1918525; HomoloGene: 51388; GeneCards: NOXRED1; OMA:NOXRED1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	77,423,523 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	87,285,506 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; sperm; ; left testis; ; right testis; ; right uterine tube; ; ventricular zone; ; monocyte; ; right lobe of liver; ; skin of leg;
	Top expressed in
	seminiferous tubule; ; spermatid; ; granulocyte; ; embryo; ; embryo; ; blastocyst; ; morula; ; otic vesicle; ; ventricular zone; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; molecular function; pyrroline-5-carboxylate reductase activity;
Cellular component	cellular component;
Biological process	biological process; L-proline biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	122945
	71275
	ENSG00000165555
	ENSMUSG00000072919
	Q6NXP6
	Q9D3S5
	NM_001113475; NM_138791; NM_001394980
	NM_027744
	NP_001106946
	NP_082020
	Wikidata
View/Edit Human	View/Edit Mouse

NADP-dependent oxidoreductase domain-containing protein 1 is a protein that in humans is encoded by the NOXRED1 gene. An alias of this gene is Chromosome 14 Open Reading Frame 148 (c14orf148)^[5]. This gene is located on chromosome 14, at 14q24.3.^[5]^[6] NOXRED1 is predicted to be involved in pyrroline-5-carboxylate reductase activity as part of the L-proline biosynthetic pathway.^[5] It is expressed in a wide variety of tissues at a relatively low level, including the testes, thyroid, skin, small intestine, brain, kidney, colon, and more.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165555 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000072919 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c ^d "NOXRED1 NADP dependent oxidoreductase domain containing 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-09-18.
^ "Human hg38 chr14:77,394,021-77,423,523 UCSC Genome Browser v437". genome.ucsc.edu. Retrieved 2022-09-28.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165555 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000072919 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] "NOXRED1 NADP dependent oxidoreductase domain containing 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-09-18.

[:1-6] "Human hg38 chr14:77,394,021-77,423,523 UCSC Genome Browser v437". genome.ucsc.edu. Retrieved 2022-09-28.