NLRP11 information

NLRP11
Identifiers
Aliases	NLRP11, CLR19.6, NALP11, NOD17, PAN10, PYPAF6, PYPAF7, NLR family, pyrin domain containing 11, NLR family pyrin domain containing 11
External IDs	OMIM: 609664; HomoloGene: 64817; GeneCards: NLRP11; OMA:NLRP11 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,836,800 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right lobe of liver; ; testicle; ; islet of Langerhans; ; lymph node; ; gallbladder; ; renal cortex; ; thymus; ; rectum; ; appendix;
	n/a
	More reference expression data
	n/a
Orthologs
	204801
	n/a
	ENSG00000179873
	n/a
	P59045
	n/a
	NM_145007; NM_001297743
	n/a
	NP_001284672; NP_659444
	n/a
	Wikidata
View/Edit Human

NOD-like receptor family pyrin domain containing 11 is a protein that in humans is encoded by the NLRP11 gene located on the long arm of human chromosome 19q13.42. NLRP11 belongs to the NALP subfamily, part of a large subfamily of CATERPILLER. It is also known as NALP11, PYPAF6, NOD17, PAN10, and CLR19.6

Being a member of the NOD-like receptor protein (NLRP) gene family, it encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene regulates caspases in the proinflammatory signal transduction pathway. Based on studies of other members of the NLRP gene family with similar domain structures, it is predicted to form part of the multiprotein inflammasome complex.^[3]^[4]

NLRP11 is expressed mainly in immune cells, B cells, myeloid cells, and B cell lymphoma cell lines. NLRP11 is involved in the regulation of inflammatory responses in human cells.^[5]

NALPs family controls cytokines, inflammatory responses, NF-κB activation, and likely cell death and survival.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179873 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "NLRP11 NLR family pyrin domain containing 11 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-02-21.
^ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nature Reviews. Molecular Cell Biology. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
^ Ellwanger K, Becker E, Kienes I, Sowa A, Postma Y, Cardona Gloria Y, et al. (February 2018). "The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling". The Journal of Biological Chemistry. 293 (8): 2701–2710. doi:10.1074/jbc.RA117.000152. PMC 5827450. PMID 29301940.
^ Harton JA, Linhoff MW, Zhang J, Ting JP (October 2002). "Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains". Journal of Immunology. 169 (8): 4088–4093. doi:10.4049/jimmunol.169.8.4088. PMID 12370334. S2CID 40372566.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179873 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-3] "NLRP11 NLR family pyrin domain containing 11 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-02-21.

[:1-4] Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nature Reviews. Molecular Cell Biology. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.

[5] Ellwanger K, Becker E, Kienes I, Sowa A, Postma Y, Cardona Gloria Y, et al. (February 2018). "The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling". The Journal of Biological Chemistry. 293 (8): 2701–2710. doi:10.1074/jbc.RA117.000152. PMC 5827450. PMID 29301940.

[6] Harton JA, Linhoff MW, Zhang J, Ting JP (October 2002). "Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains". Journal of Immunology. 169 (8): 4088–4093. doi:10.4049/jimmunol.169.8.4088. PMID 12370334. S2CID 40372566.

NLRP11 information

and 4 Related for: NLRP11 information

NLRP11

NLRP

NACHT domain

Outline of immunology