Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound
Mycothiol (MSH or AcCys-GlcN-Ins) is an unusual thiol compound found in the Actinomycetota.[1][2] It is composed of a cysteine residue with an acetylated amino group linked to glucosamine, which is then linked to inositol.[3] The oxidized, disulfide form of mycothiol (MSSM) is called mycothione, and is reduced to mycothiol by the flavoprotein mycothione reductase.[4][5] Mycothiol biosynthesis and mycothiol-dependent enzymes such as mycothiol-dependent formaldehyde dehydrogenase and mycothione reductase have been proposed to be good drug targets for the development of treatments for tuberculosis.[6][7]
^Jothivasan VK, Hamilton CJ, (2008) Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes. Natural Product Reports, (25). 1091-1117 [1]
^Newton GL, Buchmeier N, Fahey RC (September 2008). "Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria". Microbiol. Mol. Biol. Rev. 72 (3): 471–94. doi:10.1128/MMBR.00008-08. PMC 2546866. PMID 18772286.
of mycothiol (MSSM) is called mycothione, and is reduced to mycothiol by the flavoprotein mycothione reductase. Mycothiol biosynthesis and mycothiol-dependent...
Mycothiol synthase (EC 2.3.1.189, MshD) is an enzyme with systematic name acetyl-CoA:desacetylmycothiol O-acetyltransferase. This enzyme catalyses the...
then the substrate of LmbV, which substitute ergothioneine by mycothiol. The mycothiol moiety is then cleaved by LmbE, and the product is further processed...
systematic name arseno-mycothiol:mycoredoxin oxidoreductase. This enzyme catalyses the following chemical reaction arseno-mycothiol + mycoredoxin ⇌ {\displaystyle...
glutathione as a cofactor and is reduced nonenzymatically by it Bacillithiol Mycothiol γ-L-Glutamyl-L-cysteine Haynes, William M., ed. (2016). CRC Handbook of...
\rightleftharpoons } 2 mycothiol + NADP+ in M. tuberculosis and other actinomycetes. The 2 substrates of this enzyme are mycothiol and NADPH, whereas 2...
mismatch repair genes: MSH2 MSH3 MSH4 MSH5 MSH6 Multiple system atrophy Mycothiol, an unusual thiol that is found in Actinobacteria Microsoft Surface Hub...
rancidification of oils and fats. In cells, antioxidants such as glutathione, mycothiol, or bacillithiol, and enzyme systems like superoxide dismutase, can prevent...
MSHD may refer to: Mycothiol synthase, an enzyme Michigan Department of Transportation This disambiguation page lists articles associated with the title...
et al. (January 2014). "Reengineering redox sensitive GFP to measure mycothiol redox potential of Mycobacterium tuberculosis during infection". PLOS...
knockout studies, but the activity of BshC has not been observed in vitro. Mycothiol Newton, G. L.; Rawat, M.; La Clair, J. J.; Jothivasan, V. K.; Budiarto...