Global InformationMurburn concept information
 | A major contributor to this article appears to have a close connection with its subject. (September 2021) |
In the field of enzymology, murburn is a term coined by Kelath Murali Manoj that explains the catalytic mechanism of certain redox-active proteins.[1][2][3] The term describes the equilibrium among molecules, unbound ions and radicals, signifying a process of "mild unrestricted redox catalysis".
Murburn is abstracted from "mured burning" (connoting a "closed burning", an oxidative process), and implies equilibriums involving diffusible reactive oxygen species (DRS/DROS/ROS). Though akin to the oxygen assisted combustion of fuel, unlike the flames produced in the open burning process, the biological reaction occurs in enclosed premises, is mild and may generate heat alone (and no flames). Such a reaction could also incur selective and specific electron/moiety transfers.
Further, though burning is a reaction that usually involves oxygen (aerobic process), "burning flames"[4] produced by anoxic oxidants are also well-known.[4] Therefore, the enzymes working via murburn scheme (aerobic or anaerobic) could be called murzymes and the region around the biomolecule where the DRS interacts with the final ‘substrate’ is called ‘murzone’.[5]
- ^ Venkatachalam A, Parashar A, Manoj KM (December 2016). "Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme 'active site' pocket plays a relatively 'passive role' in some enzyme-substrate interactions". In Silico Pharmacology. 4 (1): 2. doi:10.1186/s40203-016-0016-7. PMC 4760962. PMID 26894412.
- ^ Manoj KM, Gade SK, Venkatachalam A, Gideon DA (2016). "Electron transfer amongst flavo- and hemo-proteins: diffusible species effect the relay processes, not protein–protein binding". RSC Advances. 6 (29): 24121–24129. Bibcode:2016RSCAd...624121M. doi:10.1039/C5RA26122H.
- ^ Manoj KM, Parashar A, Gade SK, Venkatachalam A (23 June 2016). "Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes". Frontiers in Pharmacology. 7: 161. doi:10.3389/fphar.2016.00161. PMC 4918403. PMID 27445805.
- ^ a b Periodic Videos (2010-07-15), Fluorine - Periodic Table of Videos, retrieved 2019-03-31
- ^ Manoj KM (22 March 2018). "Debunking Chemiosmosis and Proposing Murburn Concept as the Operative Principle for Cellular Respiration". Biomedical Reviews. 28: 31. arXiv:1703.05827. doi:10.14748/bmr.v28.4450.