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Mark Mayer information


Mark Mayer
FRS
Born
Mark Lee Mayer
Alma materUniversity of Bristol (BSc)
University of London (PhD)
AwardsHarkness Fellowship[1]
Scientific career
FieldsBiophysics
Ion channels
Structural biology
Glutamate receptors[2]
InstitutionsNational Institutes of Health
ThesisInhibitory synaptic mechanisms and transmitter candidates in the rostral hypothalamus of the rat (1980)
Websiteirp.nih.gov/pi/mark-mayer

Mark Lee Mayer FRS[1][3] is scientist emeritus at the National Institutes of Health (NIH). His research investigates glutamate receptor ion channels, the major mediators of excitatory synapses in the brain. He has made numerous observations that have changed our view of receptor function and neurotransmission in the brain.[1] Major findings include discovery of the block of NMDA receptors by extracellular Mg and their high Ca permeability; analysis of the permeation and block of Ca permeable AMPA and kainate receptors by cytoplasmic polyamines; and structural studies on ligand binding, allosteric modulation, and gating using X-ray diffraction and cryoelectron microscopy.

  1. ^ a b c Anon (2019). "Dr Mark Mayer FRS". royalsociety.org. London: Royal Society. Archived from the original on 24 April 2019. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)

  2. ^ Mark Mayer publications indexed by Google Scholar Edit this at Wikidata
  3. ^ Mark Mayer publications from Europe PubMed Central

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