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MX1 information


MX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMX1, IFI-78K, IFI78, MX, MxA, MX dynamin like GTPase 1, lncMX1-215
External IDsOMIM: 147150 MGI: 97244 HomoloGene: 1844 GeneCards: MX1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144925
NM_001178046
NM_001282920
NM_002462

NM_013606

RefSeq (protein)

NP_001138397
NP_001171517
NP_001269849
NP_002453

NP_038634

Location (UCSC)Chr 21: 41.42 – 41.47 MbChr 16: 97.34 – 97.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.[5][6]

In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. Furthermore, the human orthologue MxA is a major determinant for influenza viruses of animal origin.[7] The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157601 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023341 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Haller O, Staeheli P, Kochs G (Jul 2007). "Interferon-induced Mx proteins in antiviral host defense". Biochimie. 89 (6–7): 812–8. doi:10.1016/j.biochi.2007.04.015. PMID 17570575.
  6. ^ a b "Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)".
  7. ^ Ciminski, Kevin; Chase, Geoffrey; Beer, Martin; Schwemmle, Martin (2021). "Influenza A Viruses: Understanding Human Host Determinants". Trends in Molecular Medicine. 27 (2): 104–112. doi:10.1016/j.molmed.2020.09.014. PMID 33097424. S2CID 225058479.

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Ferris goes into the season as the reigning champion in the MX1 class, after winning his fourth MX1 title in the previous season. Wilson Todd won his fourth...

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Championship motocross competition. It consisted of three different classes; MX1 and MX2 classes over 15 events beginning on April 4 in Sevlievo, Bulgaria...

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2024 French Elite Motocross Championship

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June. Swiss rider Valentin Guillod is the reigning champion in the Elite MX1 class, after winning his first title in 2023. Pierre Goupillon is the reigning...

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Tony Cairoli

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his MX1 world championship in 2010. Riding for the Red Bull Factory KTM team, as well as being the first since Stefan Everts in 2006 to defend the MX1 championship...

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Motocross World Championship

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as a move towards environmentally friendlier four-stroke engines. The new MX1 class became the premier class, allowing two-stroke engines of up to 250cc...

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2023 ProMX Championship

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round were a one-day format. Aaron Tanti was the reigning champion in the MX1 class, after winning his maiden title in 2022. Ultimately, Tanti was not...

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2006 FIM Motocross World Championship

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Championship was the 50th F.I.M. Motocross Racing World Championship season. In the MX1 class, Stefan Everts took his tenth world title in what was his final season...

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2023 New Zealand Motocross Championship

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to the COVID-19 pandemic. Hamish Harwood was the reigning champion in the MX1 category, after taking his fifth national title in 2021. However, he would...

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2023 British Motocross Championship

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season. Tommy Searle started the season as the reigning champion in the MX1 class after picking up his fourth title in 2022. In the MX2 class, Conrad...

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2023 French Elite Motocross Championship

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from March to July. Milko Potisek was the reigning champion in the Elite MX1, after winning his first title in 2022. However, it would be Swiss grand...

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Motocross

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is the main UK off-road competition and organised into classes of MX1 and MX2. MX1 is for 250  cc to 450 cc (fourstroke) and MX2 for 175 cc to 250 cc...

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2024 Italian Prestige Motocross Championship

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March to late September. Alberto Forato is the reigning champion in the MX1 Elite class, after winning his second title in 2023. Cas Valk is the reigning...

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2024 Spanish Motocross Championship

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from February to October. José Butrón is the reigning champion in the Elite-MX1, after winning his ninth title in 2023. Gerard Congost is the reigning champion...

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Ken De Dycker

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championship. The 2013 season was an even bigger success seeing him finish 3rd in MX1. He's established himself as a reliable back up rider for 8 time world champion...

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Max Nagl

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World Championship season, he finished second to Antonio Cairoli in the MX1-GP series. Nagl was a member of the winning German team at the 2012 Motocross...

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2013 FIM Motocross World Championship

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of riders with riders teams announced for the first MXGP of the 2013 FIM MX1 and MX2 World Championships on February 16, 2013. "2013 FIM Motocross calendar"...

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2024 British Motocross Championship

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Championship season. Conrad Mewse starts the season as the reigning champion in the MX1 class after picking up his fourth title in 2023. In the MX2 class, Swedish...

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2009 FIM Motocross World Championship

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I.M. Motocross Racing World Championship season. Antonio Cairoli won the MX1 title for Yamaha, Marvin Musquin claimed the MX2 title for KTM and Pierre...

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Keisuke Itagaki

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design "新アニメーションシリーズ『バキ』2018年6月25日より、NETFLIXにて先行配信スタート! 2018年7月1日より、TOKYO MX1ほかにてTV放送開始" (PDF) (in Japanese). TMS Entertainment. p. 2. Archived from the...

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2007 FIM Motocross World Championship

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Championship was the 51st F.I.M. Motocross Racing World Championship season. In the MX1 class, Steve Ramon took his second world title despite not winning a Grand...

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Christophe Pourcel

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in the MX1 world championship. He joined his brother Sébastien in the Team CLS Monster Energy Kawasaki Pro Circuit team competing in the MX1 world championship...

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Harri Kullas

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across Europe. In the UK-based MX Nationals series Kullas has taken the MX1 title three times as well as winning the overall Pro Fastest 40 ranking in...

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Kan 11

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aired coverage of the 2018 FIFA World Cup in 4K ultra-high-definition. "MX1 enables 4k/UHD FIFA World Cup across Israel". Broadband TV News. 2018-05-14...

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Tanel Leok

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Groot. Leok claimed his first podium in FIM Motocross World Championships MX1 class on 2 April 2006 at Zolder, Belgium. This contract was renewed for another...

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Josh Coppins

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racing in 2012. 2009: 6th MX1 World Championship, winner of 1 GP 2008: 5th MX1 World Championship, winner of 1 GP 2007: 3rd MX1 World Championship, winner...

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