NAD-dependent methylenetetrahydrofolate dehydrogenase 2-like protein (MTHFD2L), also known as bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, is an enzyme that in humans is encoded by the MTHFD2L gene on chromosome 4.[5][6] This enzyme localizes to the inner mitochondrial membrane, where it performs the NADP+-dependent dehydrogenase/cyclohydrolase activity as part of the mitochondrial pathway to convert folate to formate.[7]
It is associated with fluctuations in cytokine secretion in response to viral infections and vaccines.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000163738 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029376 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
(MTHFD2L), also known as bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, is an enzyme that in humans is encoded by the MTHFD2L gene...
protein U MMAA: methylmalonic aciduria (cobalamin deficiency) cblA type MTHFD2L: NAD-dependent methylenetetrahydrofolate dehydrogenase 2-like protein MYL5:...