dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
structural constituent of ribosome
RNA binding
Cellular component
mitochondrial inner membrane
ribosome
mitochondrion
mitochondrial small ribosomal subunit
Biological process
mitochondrial translational elongation
mitochondrial translational termination
mitochondrial translation
protein biosynthesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
54460
66292
Ensembl
ENSG00000266472
ENSMUSG00000054312
UniProt
P82921
P58059
RefSeq (mRNA)
NM_031901 NM_018997
NM_078479 NM_001355759
RefSeq (protein)
NP_061870 NP_114107
NP_510964 NP_001342688
Location (UCSC)
Chr 1: 150.29 – 150.31 Mb
Chr 3: 95.77 – 95.78 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
28S ribosomal protein S21, mitochondrial is a protein that in humans is encoded by the MRPS21 gene.[5][6]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and assist protein synthesis within the mitochondrion.[5] Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family.[6] Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q.[7] Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000266472 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000054312 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abKenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (September 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
^ abCavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (June 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
^Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
^"Entrez Gene: MRPS21 mitochondrial ribosomal protein S21".
protein S21, mitochondrial is a protein that in humans is encoded by the MRPS21 gene. Mammalian mitochondrial ribosomal proteins are encoded by nuclear...