MGST2 information

MGST2
Identifiers
Aliases	MGST2, GST2, MGST-II, microsomal glutathione S-transferase 2
External IDs	OMIM: 601733; MGI: 2448481; HomoloGene: 1811; GeneCards: MGST2; OMA:MGST2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	139,740,745 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	51,590,098 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; secondary oocyte; ; mucosa of esophagus; ; rectum; ; right lobe of liver; ; gallbladder; ; olfactory zone of nasal mucosa; ; right adrenal cortex; ; left adrenal gland; ; apex of heart;
	Top expressed in
	gastric mucosa; ; epithelium of stomach; ; mucous cell of stomach; ; pyloric antrum; ; granulocyte; ; duodenum; ; Paneth cell; ; jejunum; ; ileum; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	enzyme activator activity; leukotriene-C4 synthase activity; transferase activity; glutathione transferase activity; protein binding; glutathione peroxidase activity;
Cellular component	integral component of membrane; intracellular membrane-bounded organelle; organelle membrane; plasma membrane; cytoplasm; endoplasmic reticulum membrane; endoplasmic reticulum; nuclear envelope; membrane;
Biological process	glutathione derivative biosynthetic process; leukotriene metabolic process; leukotriene biosynthetic process; glutathione biosynthetic process; response to lipopolysaccharide; positive regulation of catalytic activity; response to organonitrogen compound; xenobiotic metabolic process; cellular oxidant detoxification; lipid metabolism; membrane lipid catabolic process; positive regulation of inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	4258
	211666
	ENSG00000085871
	ENSMUSG00000074604
	Q99735
	A2RST1
	NM_001204366; NM_001204367; NM_001204368; NM_002413
	NM_174995; NM_001310482
	NP_001191295; NP_001191296; NP_001191297; NP_002404
	NP_001297411; NP_778160
	Wikidata
View/Edit Human	View/Edit Mouse

Microsomal glutathione S-transferase 2 is an enzyme that in humans is encoded by the MGST2 gene.^[5]^[6]

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000085871 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074604 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jakobsson PJ, Mancini JA, Ford-Hutchinson AW (Oct 1996). "Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase". J Biol Chem. 271 (36): 22203–10. doi:10.1074/jbc.271.36.22203. PMID 8703034.
^ ^a ^b "Entrez Gene: MGST2 microsomal glutathione S-transferase 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000085871 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074604 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8703034-5] Jakobsson PJ, Mancini JA, Ford-Hutchinson AW (Oct 1996). "Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase". J Biol Chem. 271 (36): 22203–10. doi:10.1074/jbc.271.36.22203. PMID 8703034.

[entrez-6] "Entrez Gene: MGST2 microsomal glutathione S-transferase 2".

MGST2 information

and 4 Related for: MGST2 information

MGST2

Leukotriene C4

Eicosanoid

MAPEG family