Global InformationLutzner cells information
| Lutzner cells | |
|---|---|
 A histological view of Lutzner cells surrounded by erythrocytes in a blood smear. | |
| Anatomical terminology [edit on Wikidata] |
Lutzner cells were discovered by Marvin A. Lutzner, Lucien-Marie Pautrier, and Albert Sézary. These cells are described as the smaller forms of Sézary cells, or Sézary-Lutzner[1] cells, and the two variants are recognised as being morphologically different. Aggregates of these cells in mycosis fungoides are known as a Pautrier's microabscesses. They are a form of T-lymphocytes that has been mutated[2] This atypical form of T-lymphocytes contains T-cell receptors on the surface and is found in both the dermis and epidermis layers of the skin. Since Lutzner cells are a mutated form of T-lymphocytes, they develop in bone marrow and are transported to the thymus is order to mature.[3] The production and maturation stages occur before the cell has developed a mutation. Lutzner cells can form cutaneous T-cell lymphoma, which is a form of skin cancer.[4]
- ^ Marta, Gustavo Nader; Gouvêa, Carolina Bueno de; Ferreira, Stéfani Bertolucci Estevam; Hanna, Samir Abdallah; Haddad, Cecília Maria Kalil; Silva, João Luis Fernandes da (2011). "Micose fungoide: relato de caso tratado com radioterapia". Anais Brasileiros de Dermatologia. 86 (3): 561–564. doi:10.1590/s0365-05962011000300022. PMID 21738977.
- ^ Kumar, V., et al. (2014). Robbins & Cotran Pathologic Basis of Disease, 9th Edition. Philadelphia, Pennsylvania: Elsevier Health Sciences.
- ^ Cite error: The named reference
Ehrlichwas invoked but never defined (see the help page). - ^ Lutzner, M. A. (1985). History of 2 cells in T cell lymphomas and leukemias: the cerebriform Lutzner cell in Sézary syndrome and the polylobulated or polypetaloid cell in acute T cell lymphoma/leukemia. Hautarzt, 36(12). 657-662.