Luliconazole information

Luliconazole
Clinical data
Trade names	Luzu, Luzarn, Lulicon, LULY, Zyluli,Luris
Routes of; administration	Topical
ATC code	D01AC18 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	>99%
Identifiers
	IUPAC name (2E)-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)acetonitrile;
CAS Number	187164-19-8;
PubChem CID	3003141;
ChemSpider	2273807;
UNII	RE91AN4S8G;
CompTox Dashboard (EPA)	DTXSID3048607 ;
Chemical and physical data
Formula	C14H9Cl2N3S2
Molar mass	354.27 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1[C@H](S/C(=C(\C#N)/N2C=CN=C2)/S1)C3=C(C=C(C=C3)Cl)Cl;
	InChI InChI=1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1; Key:YTAOBBFIOAEMLL-REQDGWNSSA-N;

Luliconazole, trade names Luzu among others, is an imidazole antifungal medication.^[2] As a 1% topical cream, It is indicated for the treatment of athlete's foot, jock itch, and ringworm caused by dermatophytes such as Trichophyton rubrum, Microsporum gypseum,^[3] and Epidermophyton floccosum.^[1]

^ ^a ^b "LUZU (luliconazole) Cream, 1%. Full Prescribing Information" (PDF). Valeant Pharmaceuticals North America LLC. Retrieved 1 October 2015.
^ Gupta AK, Daigle D (2016). "A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections". Infection and Drug Resistance. 9: 1–6. doi:10.2147/IDR.S61998. PMC 4723097. PMID 26848272.
^ "FDA approves luliconazole for tinea pedis". November 19, 2013. Archived from the original on 16 January 2014. Retrieved 14 January 2014.

[PI-1] "LUZU (luliconazole) Cream, 1%. Full Prescribing Information" (PDF). Valeant Pharmaceuticals North America LLC. Retrieved 1 October 2015.

[Gupta_2016-2] Gupta AK, Daigle D (2016). "A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections". Infection and Drug Resistance. 9: 1–6. doi:10.2147/IDR.S61998. PMC 4723097. PMID 26848272.

[3] "FDA approves luliconazole for tinea pedis". November 19, 2013. Archived from the original on 16 January 2014. Retrieved 14 January 2014.

Luliconazole information

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Luliconazole

Antifungal

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ATC code D01

Steroidogenesis inhibitor

Clinical data


Trade names	Luzu, Luzarn, Lulicon, LULY, Zyluli,Luris
Routes of administration	Topical
ATC code	D01AC18 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding	>99%^[1]
Identifiers
IUPAC name (2E)-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)acetonitrile
CAS Number	187164-19-8
PubChem CID	3003141
ChemSpider	2273807
UNII	RE91AN4S8G
CompTox Dashboard (EPA)	DTXSID3048607
Chemical and physical data
Formula	C₁₄H₉Cl₂N₃S₂
Molar mass	354.27 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1[C@H](S/C(=C(\C#N)/N2C=CN=C2)/S1)C3=C(C=C(C=C3)Cl)Cl
InChI InChI=1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1 Key:YTAOBBFIOAEMLL-REQDGWNSSA-N