Stanford University, Boston University, Johns Hopkins University
Awards
Order of the Crown of Belgium, Officer of the Royal Order of the Lion[1]
Scientific career
Fields
Pathology
Institutions
Rockefeller Institute
External videos
Unsung Hero: Louise Pearce. Image of blood smear from a patient with African trypanosomiasis, showing trypanosomes.
Louise Pearce (March 5, 1885 – August 10, 1959) was an American pathologist at the Rockefeller Institute who helped develop a treatment for African sleeping sickness (trypanosomiasis).[2][3] Sleeping sickness was a fatal epidemic which had devastated areas of Africa, killing two-thirds of the population of the Uganda protectorate between 1900 and 1906 alone.[4] With chemists Walter Abraham Jacobs and Michael Heidelberger and pathologist Wade Hampton Brown, Pearce worked to develop and test arsenic-based drugs for its treatment. In 1920, Louise Pearce traveled to the Belgian Congo where she designed and carried out a drug testing protocol for human trials to establish tryparsamide's safety, effectiveness, and optimum dosage.[5] Tryparsamide proved successful in combating the fatal epidemic, curing 80% of cases.[6]
For her work on sleeping sickness, Pearce received the Order of the Crown of Belgium (1920[1] or 1921[6]). In 1953, Belgium further honored her, appointing Pearce and her co-workers as Officers of the Royal Order of the Lion.[1]
Pearce also successfully developed treatment protocols to apply tryparsamide to syphilis. She spent much of her career studying animal models of cancer.
^ abcCite error: The named reference Ogilvie was invoked but never defined (see the help page).
^ ab"A Guide to the Louise Pearce papers, Rockefeller University Faculty". Rochefeller Archive Center. Retrieved 14 October 2014.
^Cite error: The named reference Burstyn was invoked but never defined (see the help page).
^Cite error: The named reference Kirkland was invoked but never defined (see the help page).
^Cite error: The named reference Corner1965 was invoked but never defined (see the help page).
^ ab"The First Drug for African Sleeping Sickness". The Rockefeller University. Retrieved 13 October 2014.
LouisePearce (March 5, 1885 – August 10, 1959) was an American pathologist at the Rockefeller Institute who helped develop a treatment for African sleeping...
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Global Information
Unsung Hero: Louise Pearce. Image of blood smear from a patient with African trypanosomiasis, showing trypanosomes.