U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene.[5][6]
This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000128534 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000044155 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
^ ab"Entrez Gene: LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene. This gene is a member of the LSm family and encodes...
proteins (LSm1, LSm2, LSm3, LSm4, LSm5, LSm6 and LSm7), with the similar LSm8 protein identified later. In the bacterium Escherichia coli, the Sm-like...
splicing.[supplied by OMIM] LSM2 has been shown to interact with DDX20, LSM3, LSM8 and LSM7. GRCh38: Ensembl release 89: ENSG00000204392 – Ensembl, May 2017...