Global InformationKurloff cell information
| Kurloff cell | |
|---|---|
 Kurloff cell and a lymphocyte in a Guinea pig | |
| Details | |
| Location | blood and organs of guinea pigs and capybara |
| Anatomical terms of microanatomy [edit on Wikidata] | |
Kurloff cells (also known as Foà-Kurloff cells,[1]) were described as mononuclear cells in the peripheral blood and organs of the guinea pig, capybara,[2] paca, agouti and cavie.[3] The Kurloff cell contains a characteristic proteoglycan-containing inclusion body. In the guinea pig, Kurloff cells are more numerous in the adult female than the adult male.[4] A marked increase in the number of circulating Kurloff cells is present in the peripheral blood during pregnancy and after estrogen treatment in male and female animals.[1] A relatively smaller number of cells take place in immature, non-pregnant, and non-estrogen-treated animals. The exact function of Kurloff cells remains unknown, but it has some of the characteristics of both monocytes and lymphocytes. In guinea-pigs, it has been proposed that Kurloff cells mainly involve in the function of the immune system, such as acting as a natural killer cell and preventing damage to the trophoblast by maternal defensive cells. Also, Kurloff cells present antibody-dependent cytotoxic activity in vitro.[5][6][7]
- ^ a b Ledingham JC (1940). "Sex hormones and the Foà-Kurloff cell". The Journal of Pathology and Bacteriology. 50 (2): 201–219. doi:10.1002/path.1700500202.
- ^ Cite error: The named reference
:0was invoked but never defined (see the help page). - ^ Revell PA (1977). "The Kurloff cell". International Review of Cytology. 51: 275–314. doi:10.1016/S0074-7696(08)60229-6. ISBN 978-0-12-364351-3. PMID 201582.
- ^ Cite error: The named reference
:5was invoked but never defined (see the help page). - ^ Fox JG, Anderson LC, Loew FM, Quimby FW (2002). Laboratory Animal Medicine (2nd ed.). Academic Press. p. 206. ISBN 978-0-08-053533-3.
- ^ Debout C, Quillec M, Izard J (September 1984). "Natural killer activity of Kurloff cells: a direct demonstration on purified Kurloff cell suspensions". Cellular Immunology. 87 (2): 674–7. doi:10.1016/0008-8749(84)90034-0. PMID 6467387.
- ^ Eremin O, Wilson AB, Coombs RR, Ashby J, Plumb D (October 1980). "Antibody-dependent cellular cytotoxicity in the guinea pig: the role of the Kurloff cell". Cellular Immunology. 55 (2): 312–27. doi:10.1016/0008-8749(80)90164-1. PMID 7428051.