Krapcho decarboxylation is a chemical reaction used to manipulate certain organic esters.[1] This reaction applies to esters with a beta electron-withdrawing group (EWG).
The reaction proceeds by nucleophilic dealkylation of the ester by the halide followed by decarboxylation, followed by hydrolysis of the resulting stabilized carbanion.[2]
ZCH2CO2CH3 + I− + H2O → ZCH3 + CH3I + CO2 + OH−
^Cite error: The named reference :1 was invoked but never defined (see the help page).
^Poon, Po. S.; Banerjee, Ajoy K.; Laya, Manuel S. (2011). "Advances in the Krapcho Decarboxylation". Journal of Chemical Research. 35 (2): 67–73. doi:10.3184/174751911X12964930076403. ISSN 1747-5198.
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