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Karen Joy Shaw information


Karen Joy Shaw is an American microbiologist and discoverer of novel antifungal and antibacterial compounds.  She is best known for her work on aminoglycoside resistance in bacteria[1] as well as leading drug discovery research teams. As Senior Vice President of Biology at Trius Therapeutics, Inc.[2] her work was critical to the development of the oxazolidinone antibiotic tedizolid phosphate (Sivextro) as well as the discovery of the TriBE inhibitors,[3] a novel class of DNA gyrase/Topoisomerase IV antibacterial agents that target both Gram-positive and Gram-negative organisms.[2]  As Chief Scientific Officer at Amplyx Pharmaceuticals,[4] Shaw was responsible for the preclinical development of the novel antifungal fosmanogepix, a first-in-class broad-spectrum antifungal prodrug that is currently in Phase 2 clinical development for the treatment of invasive fungal infections.[5]  She also discovered APX2039, a unique Gwt1 inhibitor[6] that is in preclinical development for the treatment of cryptococcal meningitis.[7]

  1. ^ Shaw, K. J.; Rather, P. N.; Hare, R. S.; Miller, G. H. (1993). "Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes". Microbiological Reviews. 57 (1): 138–163. doi:10.1128/MR.57.1.138-163.1993. ISSN 0146-0749. PMC 372903. PMID 8385262.
  2. ^ manager, Community. "Karen J. Shaw". REVIVE. Retrieved 2020-12-01.
  3. ^ Tari, Leslie W.; Li, Xiaoming; Trzoss, Michael; Bensen, Daniel C.; Chen, Zhiyong; Lam, Thanh; Zhang, Junhu; Lee, Suk Joong; Hough, Grayson; Phillipson, Doug; Akers-Rodriguez, Suzanne (2013-12-26). "Tricyclic GyrB/ParE (TriBE) Inhibitors: A New Class of Broad-Spectrum Dual-Targeting Antibacterial Agents". PLOS ONE. 8 (12): e84409. Bibcode:2013PLoSO...884409T. doi:10.1371/journal.pone.0084409. ISSN 1932-6203. PMC 3873466. PMID 24386374.
  4. ^ "Karen Joy Shaw, Amplyx Pharmaceuticals Inc: Profile and Biography". Bloomberg.com. Retrieved 2020-12-01.
  5. ^ "Fosmanogepix Shows Promise as an Effective Novel Antifungal in POC Trial". Contagion Live. Retrieved 2020-12-01.
  6. ^ Viriyakosol, Suganya; Kapoor, Mili; Okamoto, Sharon; Covel, Jonathan; Soltow, Quinlyn A.; Trzoss, Michael; Shaw, Karen Joy; Fierer, Joshua (2018-11-19). "APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia". Antimicrobial Agents and Chemotherapy. 63 (2): e01715–18. doi:10.1128/AAC.01715-18. ISSN 0066-4804. PMC 6355600. PMID 30455238.
  7. ^ "Amplyx to Present New Clinical and Preclinical Data for its Two Lead Programs at Upcoming Scientific Conferences | Amplyx". Retrieved 2020-12-01.

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