KCNS2 information

KCNS2
Identifiers
Aliases	KCNS2, KV9.2, potassium voltage-gated channel modifier subfamily S member 2
External IDs	OMIM: 602906; MGI: 1197011; HomoloGene: 22465; GeneCards: KCNS2; OMA:KCNS2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	98,432,853 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	34,843,553 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; primary visual cortex; ; prefrontal cortex; ; buccal mucosa cell; ; Brodmann area 9; ; superior frontal gyrus; ; right frontal lobe; ; parietal lobe;
	Top expressed in
	medial dorsal nucleus; ; habenula; ; dorsal striatum; ; olfactory tubercle; ; substantia nigra; ; nucleus accumbens; ; anterior amygdaloid area; ; lumbar subsegment of spinal cord; ; lateral geniculate nucleus; ; piriform cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	ion channel activity; potassium channel activity; protein binding; voltage-gated ion channel activity; voltage-gated potassium channel activity;
Cellular component	perinuclear region of cytoplasm; integral component of membrane; voltage-gated potassium channel complex; plasma membrane; membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; regulation of delayed rectifier potassium channel activity; protein homooligomerization; ion transport; transmembrane transport; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	3788
	16539
	ENSG00000156486
	ENSMUSG00000050963
	Q9ULS6
	O35174
	NM_020697
	NM_001271704; NM_181317; NM_008436
	NP_065748
	NP_001258633; NP_851834
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily S member 2 is a protein that in humans is encoded by the KCNS2 gene.^[5]^[6] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156486 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050963 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M (Oct 1997). "New modulatory alpha subunits for mammalian Shab K+ channels". J Biol Chem. 272 (39): 24371–9. doi:10.1074/jbc.272.39.24371. PMID 9305895.
^ ^a ^b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156486 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050963 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9305895-5] Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M (Oct 1997). "New modulatory alpha subunits for mammalian Shab K+ channels". J Biol Chem. 272 (39): 24371–9. doi:10.1074/jbc.272.39.24371. PMID 9305895.

[pmid16382104-6] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

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