KCND3 information

KCND3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S1G, 2NZ0
Identifiers
Aliases	KCND3, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22, BRGDA9, potassium voltage-gated channel subfamily D member 3
External IDs	OMIM: 605411; MGI: 1928743; HomoloGene: 21036; GeneCards: KCND3; OMA:KCND3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	111,989,668 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	105,581,318 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; Brodmann area 23; ; middle temporal gyrus; ; parietal lobe; ; caput epididymis; ; postcentral gyrus; ; entorhinal cortex; ; corpus epididymis; ; superior frontal gyrus; ; Brodmann area 10;
	Top expressed in
	substantia nigra; ; ventral tegmental area; ; lateral geniculate nucleus; ; medial geniculate nucleus; ; habenula; ; vas deferens; ; subiculum; ; pineal gland; ; supraoptic nucleus; ; dorsal tegmental nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; transmembrane transporter binding; metal ion binding; voltage-gated ion channel activity; ion channel activity; protein binding; voltage-gated potassium channel activity; A-type (transient outward) potassium channel activity; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;
Cellular component	integral component of membrane; cell projection; membrane; voltage-gated potassium channel complex; plasma membrane; dendrite; sarcolemma; GABA-ergic synapse; integral component of postsynaptic specialization membrane; neuronal cell body;
Biological process	regulation of ion transmembrane transport; ion transport; potassium ion transport; membrane repolarization; transmembrane transport; potassium ion transmembrane transport; protein homooligomerization; membrane repolarization during cardiac muscle cell action potential; regulation of heart rate by cardiac conduction; potassium ion export across plasma membrane; membrane repolarization during ventricular cardiac muscle cell action potential; ventricular cardiac muscle cell membrane repolarization; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	3752
	56543
	ENSG00000171385
	ENSMUSG00000040896
	Q9UK17
	Q9Z0V1
	NM_004980; NM_172198; NM_001378969; NM_001378970
	NM_001039347; NM_019931
	NP_004971; NP_751948; NP_001365898; NP_001365899
	NP_001034436; NP_064315
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily D member 3 also known as K_v4.3 is a protein that in humans is encoded by the KCND3 gene.^[5]^[6]^[7] It contributes to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171385 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040896 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Postma AV, Bezzina CR, de Vries JF, Wilde AA, Moorman AF, Mannens MM (Aug 2000). "Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3". Hum Genet. 106 (6): 614–9. doi:10.1007/s004390050033. PMID 10942109.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID 11343410.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171385 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040896 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10942109-5] Postma AV, Bezzina CR, de Vries JF, Wilde AA, Moorman AF, Mannens MM (Aug 2000). "Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3". Hum Genet. 106 (6): 614–9. doi:10.1007/s004390050033. PMID 10942109.

[pmid16382104-6] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[entrez-7] Cite error: The named reference entrez was invoked but never defined (see the help page).

[oudit-8] Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID 11343410.

KCND3 information

and 9 Related for: KCND3 information

KCND3

Cardiac action potential

Spinocerebellar ataxia

List of genetic disorders

Cardiac transient outward potassium current

Brugada syndrome

Cation channel superfamily

KCND2

Potassium channel tetramerisation domain