Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is a protein that in humans is encoded by the KCNA3 gene.[5][6][7]
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes – shaker, shaw, shab, and shal – have been identified in Drosophila, and each has been shown to have human homolog(s).
This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T cell proliferation and activation. This gene appears to be intronless and is clustered together with KCNA2 and KCNA10 genes on chromosome 1.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000177272 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000047959 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG (December 1990). "Expression and chromosomal localization of a lymphocyte K + channel gene". Proceedings of the National Academy of Sciences of the United States of America. 87 (23): 9411–5. Bibcode:1990PNAS...87.9411G. doi:10.1073/pnas.87.23.9411. PMC 55175. PMID 2251283.
^Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is a protein that in humans is encoded by the KCNA3 gene. Potassium channels represent the most...
studying of clofazimine in human T cells revealed that this drug is a Kv1.3 (KCNA3) channel blocker. This indicates that clofazimine will be potentially used...
subfamily and targets the voltage-gated potassium channels KCNA2 (Kv1.2), and KCNA3 (Kv1.3). OSK3 is secreted from the venom gland of Orthochirus scrobiculosus...
family, and selectively blocks the voltage-gated potassium channel Kv1.3 (KCNA3). Odonthobuthus doriae is a scorpion species that belongs to the Buthidae...
(K+) channel-blocking peptides. An important physiological role of the KCNA3 channel, also known as KV1.3, is to help maintain large electrical gradients...
and Kv1.3. These channels are coded respectively by the genes KCNA2 and KCNA3 and their inhibition is reversible. hKv1.2 is inhibited with a Kd of 92...
multiple sclerosis (MS) treatment. In macrophages, knock-down experiments of kcna3 (gene of Kv1.3) impaired cell growth and migration, features characteristic...
for Kv1.2/KCNA2, 2245.93 nM for Kv1.6/KCNA6, 1006.48 nM for human Kv1.3/KCNA3, and 94.25 nM for the Drosophila Shaker IR channels. Competitive interaction...
region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. KCNA2 has been shown to interact with KCNA4...
assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1". Genomics. 23 (1): 295–6...
region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1 in humans. KCNA4 (Kv1.4) contains a tandem inactivation...
Lerner DJ, Abbott GW (December 2011). "KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium". FASEB Journal. 25 (12): 4264–73...
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