KAT5 information

KAT5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EKO, 2OU2, 4QQG
Identifiers
Aliases	KAT5, ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, ZC2HC5, cPLA2, lysine acetyltransferase 5, NEDFASB
External IDs	OMIM: 601409; MGI: 1932051; HomoloGene: 100661; GeneCards: KAT5; OMA:KAT5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,719,604 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,660,265 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; gastric mucosa; ; left lobe of thyroid gland; ; left uterine tube; ; popliteal artery; ; canal of the cervix; ; ganglionic eminence; ; sural nerve; ; skin of abdomen;
	Top expressed in
	spermatocyte; ; yolk sac; ; interventricular septum; ; hand; ; medial vestibular nucleus; ; cerebellar cortex; ; seminiferous tubule; ; dorsal tegmental nucleus; ; superior frontal gyrus; ; lateral hypothalamus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; transcription coactivator activity; metal ion binding; histone acetyltransferase activity; protein binding; androgen receptor binding; acetyltransferase activity; acyltransferase activity; H4 histone acetyltransferase activity; histone binding;
Cellular component	cytoplasm; transcription regulator complex; Piccolo NuA4 histone acetyltransferase complex; nucleoplasm; nucleolus; perinuclear region of cytoplasm; nucleus; Swr1 complex; NuA4 histone acetyltransferase complex; histone acetyltransferase complex;
Biological process	response to ionizing radiation; androgen receptor signaling pathway; regulation of transcription, DNA-templated; cellular response to estradiol stimulus; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of protein acetylation; positive regulation of transcription, DNA-templated; regulation of growth; viral process; negative regulation of transcription, DNA-templated; double-strand break repair via nonhomologous end joining; negative regulation of interleukin-2 production; positive regulation of transcription by RNA polymerase II; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; proteasome-mediated ubiquitin-dependent protein catabolic process; DNA replication; DNA double-strand break processing; beta-catenin-TCF complex assembly; double-strand break repair; histone acetylation; chromatin organization; histone H4 acetylation; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	10524
	81601
	ENSG00000172977
	ENSMUSG00000024926
	Q92993
	Q8CHK4
	NM_001206833; NM_006388; NM_182709; NM_182710
NM_001199247; NM_001199248; NM_001199249; NM_178637; NM_001362370;
	NM_001362371; NM_001362372
	NP_001193762; NP_006379; NP_874368; NP_874369
NP_001186176; NP_001186177; NP_001186178; NP_848752; NP_001349299;
	NP_001349300; NP_001349301
	Wikidata
View/Edit Human	View/Edit Mouse

Histone acetyltransferase KAT5 is an enzyme that in humans is encoded by the KAT5 gene.^[5]^[6] It is also commonly identified as TIP60.

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172977 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024926 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kamine J, Elangovan B, Subramanian T, Coleman D, Chinnadurai G (Feb 1996). "Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator". Virology. 216 (2): 357–66. doi:10.1006/viro.1996.0071. PMID 8607265.
^ ^a ^b "Entrez Gene: HTATIP HIV-1 Tat interacting protein, 60kDa". Archived from the original on 2024-04-27. Retrieved 2024-04-27.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172977 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024926 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8607265-5] Kamine J, Elangovan B, Subramanian T, Coleman D, Chinnadurai G (Feb 1996). "Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator". Virology. 216 (2): 357–66. doi:10.1006/viro.1996.0071. PMID 8607265.

[entrez-6] "Entrez Gene: HTATIP HIV-1 Tat interacting protein, 60kDa". Archived from the original on 2024-04-27. Retrieved 2024-04-27.

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