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Juven information


Juven is a medical food that is manufactured by Abbott Laboratories and used to provide nutritional support under the care of a physician in individuals with muscle wasting due to AIDS or cancer, to promote wound healing following surgery or injury, or when otherwise recommended by a medical professional.[1][2][3] It is a powdered nutritional supplement that contains 3 grams of calcium β-hydroxy β-methylbutyrate, 14 grams of L-arginine, and 14 grams of L-glutamine per two daily servings.[1]

Juven has been shown to increase lean body mass during clinical trials in individuals with AIDS and cancer, but not rheumatoid cachexia.[4][5][6] Clinical trials with Juven for AIDS have also demonstrated improvements in immune status, as measured by a reduced HIV viral load relative to controls and higher CD3+ and CD8+ cell counts.[note 1][4][6] The efficacy of Juven for the treatment of cancer cachexia was also examined in a phase 3 clinical trial which found a strong trend (i.e., p=.08) for an improvement in lean body mass relative to controls;[4][5][8] however, according to the authors of the trial itself and a systematic review that included it, the trial did not adequately test the ability of Juven to prevent or reverse the loss of lean body mass in individuals with cancer cachexia since the majority of participants did not complete the study.[4][8] Further research involving the treatment of cancer cachexia with Juven over a period of several months is required to adequately determine treatment efficacy.[4][5]

  1. ^ a b "Product Information: Juven" (PDF). Abbott Nutrition. 7 May 2016. Retrieved 6 October 2022.
     • Administer orally or as a modular via feeding tube ...
     • Use under medical supervision.
     • Nutravigor® (CaHMB, calcium β-hydroxy-β-methylbutyrate) – a metabolite of leucine that regulates protein metabolism in muscle cells.4
     • Arginine – a conditionally essential amino acid5 that is a precursor of nitric oxide, which supports blood flow.6
     • Glutamine – a conditionally essential amino acid5 that stimulates fibroblastic collagen production7,8 and supports nitrogen metabolism.5,9
  2. ^ Linn J (13 May 2013). "Proteins in Human Health and Performance". Iowa State University. Archived from the original on 27 August 2016. Retrieved 31 July 2016. HMB is currently marketed nationally by Abbott Laboratories as Revigor™, which is a component of Ensure® Muscle Health, and Juven®, which is a nutritional beverage that is clinically shown to promote healing after injury or surgery.
  3. ^ Khamsi R (May 2013). "Rethinking the formula". Nat. Med. 19 (5): 525–529. doi:10.1038/nm0513-525. PMID 23652097. The questions about what defines a medical food will likely grow as the market does—and that market now extends far beyond PKU and other inherited metabolic disorders. Vitamax, for example, is a chewable tablet designed to meet the specific vitamin needs of people with cystic fibrosis; Vascazen, meanwhile, contains purified omega-3 fatty acids for people with cardiovascular disease; Abbott Nutrition's Juven provides nutrients to people with HIV or AIDS experiencing excessive weight loss due to disease; ...
  4. ^ a b c d e Molfino A, Gioia G, Rossi Fanelli F, Muscaritoli M (December 2013). "Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials". Amino Acids. 45 (6): 1273–1292. doi:10.1007/s00726-013-1592-z. PMID 24057808. S2CID 254079612. Interesting results were observed during cancer, notably, patients with advanced (stage IV) cancer receiving a HMB/ARG/GLN supplement gained 0.95 ± 0.66 kg of BM in 4 weeks and a change in body composition (FFM increase of 1.12 ± 0.68 kg). The FFM increase was maintained over the 24 weeks (May et al. 2002). Human immunodeficiency virus (HIV)-infected patients gained 3.0 ± 0.5 kg of BM after 8 weeks of HMB/ARG/GLN supplementation, mainly FFM (2.55 ± 0.75 kg). HMB/ARG/GLN supplementation also improved immune status, measured by increasing CD3 and CD8 cells and decreasing the HIV viral load. ... These results show that HMB/ARG/GLN can be safely used to treat AIDS- and cancer-related muscle wasting (Rathmacher et al. 2004). Berk et al. (2008) showed a strong trend towards higher FFM and BM in HMB/ARG/GLN-supplemented patients but they did not adequately test the ability of HMB/ARG/GLN to reverse or prevent cancer cachexia because most of patients did not complete the study. It was also demonstrated that both placebo and experimental amino acid mixtures significantly increased FFM, total body protein, arms and legs lean mass, and measures of physical function in rheumatoid arthritis patients but HMB/ARG/GLN supplementation was not superior to placebo in reversing rheumatoid cachexia (Marcora et al. 2005).
  5. ^ a b c Mochamat, Cuhls H, Marinova M, Kaasa S, Stieber C, Conrad R, Radbruch L, Mücke M (July 2016). "A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in cancer: a European Palliative Care Research Centre cachexia project". Journal of Cachexia, Sarcopenia and Muscle. 8 (1): 25–39. doi:10.1002/jcsm.12127. PMC 5326814. PMID 27897391. Looking at studies with proteins and other dietary supplements the combination of HMB, arginine, and glutamine showed interesting results ... In one study, 32 patients gained an average of about 2 kg of body weight.[21] This study was one of three studies confirming the positive effects of this combination in a variety of diagnoses/conditions such as HIV/AIDS patients and healthy adults.[40] Another study, on a far larger sample base of around 470 cancer patients, found no significant difference with regard to LBM after 8 weeks however a strong trend in the direction of an increase in LBM as measured by both bio-impedance and skin-fold measurements.[22] In summary, the effect of the combination of HMB, arginine, and glutamine on weight gain should be investigated in further studies on cancer patients investigating time periods of several months.
  6. ^ a b Rahman A, Wilund K, Fitschen PJ, Jeejeebhoy K, Agarwala R, Drover JW, Mourtzakis M (July 2014). "Elderly persons with ICU-acquired weakness: the potential role for β-hydroxy-β-methylbutyrate (HMB) supplementation?". Journal of Parenteral and Enteral Nutrition. 38 (5): 567–575. doi:10.1177/0148607113502545. PMID 24072740.
  7. ^ Barth SD, Kaaks R, Johnson T, Katzke V, Gellhaus K, Schulze JJ, Olek S, Kühn T (September 2016). "The Ratio of Regulatory (FOXP3+) to Total (CD3+) T Cells Determined by Epigenetic Cell Counting and Cardiovascular Disease Risk: A Prospective Case-cohort Study in Non-diabetics". eBioMedicine. 11: 151–156. doi:10.1016/j.ebiom.2016.07.035. PMC 5049920. PMID 27499494.
  8. ^ a b Berk L, James J, Schwartz A, Hug E, Mahadevan A, Samuels M, Kachnic L (October 2008). "A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122)". Supportive Care in Cancer. 16 (10): 1179–1188. doi:10.1007/s00520-008-0403-7. PMID 18293016. S2CID 28498883. RESULTS: Only 37% of the patients completed protocol treatment. ... CONCLUSION: This trial was unable to adequately test the ability of beta-hydroxy beta-methylbutyrate, glutamine, and arginine to reverse or prevent lean body mass wasting among cancer patients. ... However, there was a strong trend towards an increased body mass among patients taking the Juven compound


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(Richard, 1904) Professionnelles beautés (Juven, 1905) Altesses sérénissimes (Juven, 1907) Assemblée de notables (Juven, 1908) Saints d'Israël (Maison du livre...

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doi:10.1007/BF01217730. MR 0990772. S2CID 14951363. Putrov, Pavel; Wang, Juven; Yau, Shing-Tung (2017). "Braiding Statistics and Link Invariants of Bosonic/Fermionic...

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Cucullo – drums, percussion Christian Sindico – bass guitar, backing vocals Juven Pelingon – lead guitars, rhythm guitar Howie Ramos – rhythm guitar Alfie...

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324. Bibcode:1982PhLB..117..324W. doi:10.1016/0370-2693(82)90728-6. Wang, Juven; Wen, Xiao-Gang; Witten, Edward (May 2019). "A New SU(2) Anomaly". Journal...

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Abbott Laboratories

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Ensure and ZonePerfect) and special dietary needs (e.g., Glucerna and Juven) Diagnostics: core lab, molecular, point of care, rapid diagnostics and...

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129..393D. doi:10.1007/BF02096988. S2CID 2163226. Putrov, Pavel; Wang, Juven; Yau, Shing-Tung (September 2017). "Braiding Statistics and Link Invariants...

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ISSN 0010-3616, http://projecteuclid.org/euclid.cmp/1104161738 Yetter 1993 Wang, Juven; Wen, Xiao-Gang (13 March 2015). "Boundary Degeneracy of Topological Order"...

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List of brand name food products

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Energen (cereal drink) Frugo Gold Spot Goombay Punch Höpt Horlicks Jūrokucha Juven Kalleh Dairy Killer Shake Kinnie Kinohimitsu Maltos-Cannabis Manhattan Special...

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translated into French by Bojidar Karageorgevitch and published by F. Juven (Paris) in 1908 with an introduction by Anatole France. She drafted her...

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Charlotte of Belgium

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politique, le roi du Congo, l'homme privé (in French). Paris: Librairie Félix Juven.. Kerckvoorde 1981, p. 269. "Les funérailles de la princesse Charlotte"...

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List of Latin words with English derivatives

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jurat, juration, juratory, jurisdiction, jury, justice iuvenis juvenis juven- young junior, juniorate, juniority, juvenile, juvenilia, juvenility, rejuvenate...

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Anyon

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1103/PhysRevLett.113.080403. ISSN 1079-7114. PMID 25192079. S2CID 23104804. Wang, Juven; Wen, Xiao-Gang (15 January 2015). "Non-Abelian String and Particle Braiding...

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Le Rire

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issue in April 1971. Founded in Paris during the Belle Époque by Felix Juven, Le Rire appeared as typical Parisians began to achieve more education,...

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Gene structure

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Valenzuela Classic

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# Name Term Ref. 1 Chris Gavina 2018–2018–2019 2 Eric Samson 2018 3 Juven Formacil 2019 4 Gerry Esplana 2019 5 Ronjay Enrile 2019–2020 6 Aldrin Morante...

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Das Lied von der Erde

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Press) ISBN 978-0-231-09676-8. Judith Gautier. Le livre de Jade. Felix Juven. Paris. 1867. Second, revised edition 1902. S. Spencer. Wagner Remembered...

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Group cohomology

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Normale Supérieure. Série 4. 7 (2): 235–272. doi:10.24033/asens.1269. Wang, Juven C.; Gu, Zheng-Cheng; Wen, Xiao-Gang (22 January 2015). "Field-Theory Representation...

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Topological degeneracy

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351K. doi:10.1007/s00220-012-1500-5. ISSN 1432-0916. S2CID 3070055. Wang, Juven; Wen, Xiao-Gang (13 March 2015). "Boundary Degeneracy of Topological Order"...

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