Global InformationJerrold Schwaber information
Jerrold Schwaber (May 24, 1947 – June 6, 2014) was an American biologist and geneticist. In 1973 he described, with Edward Cohen, a method of producing antibodies involving human–mouse hybrid cells, or hybridomas. They fused "mouse myeloma cells secreting immunoglobulin of known specificity and human peripheral blood lymphocytes not secreting detectable immunoglobulin. The hybrid cells continued secretion of mouse immunoglobulin and initiate synthesis and secretion of human immunoglobulin."[1] The antibody producing cells did not survive long and the antigens that the antibodies targeted remained unknown.[2] In 1975, Georges Köhler, César Milstein, and Niels Kaj Jerne, succeeded in making hybridomas that made antibodies to known antigens and that were immortalized.[2] They shared the Nobel Prize in Physiology or Medicine in 1984 for the discovery. His work in laying the foundation for modern monoclonal antibody technology is recognized.[2][3]
- ^ Schwaber J, Cohen EP. Human x mouse somatic cell hybrid clone secreting immunoglobulins of both parental types. Nature. 1973 Aug 17;244(5416):444-7. PMID 4200460
- ^ a b c Dr Lara Marks for What is Biotechnology? A Healthcare Revolution in the Making: The Story of César Milstein and Monoclonal Antibodies: Making monoclonal antibodies
- ^ Cambrosio, A.; Keating, P. (1992). "Between fact and technique: the beginnings of hybridoma technology". Journal of the History of Biology 25 (2): 175–230. doi:10.1007/BF00162840. PMID 11623041