Global InformationJason Micklefield information
Jason Micklefield | |
|---|---|
 Professor Jason Micklefield at the Manchester Institute of Biotechnology | |
| Born | Jason Micklefield |
| Alma mater | Hull University (BSc) University of Cambridge (PhD) |
| Known for | Discovery, characterisation and engineering of enzymes and biosynthetic pathways. Biocatalysis and integrated catalysis. Modified nucleic acids and orthogonal riboswitches. |
| Scientific career | |
| Fields | Organic Chemistry, Biochemistry and Molecular Biology |
| Institutions | University of Washington
Birkbeck College, University of London University of Manchester |
| Doctoral advisor | Prof. Sir Alan Battersby |
| Website | https://www.micklefieldlab.chemistry.manchester.ac.uk/ |
Jason Micklefield is a British Biochemist and a professor in the Department of Chemistry at The University of Manchester. His research involves the discovery, characterisation and engineering of biosynthetic pathways to new bioactive natural products, particularly antibiotics.[1][2][3] He is also interested in the discovery, structure, mechanism and engineering of enzymes for synthetic applications, including the integration of enzymes with chemocatalysis for telescoping routes to pharmaceuticals and other valuable products.[4][5][6]
- ^ Thong, Wei Li; Zhang, Yingxin; Zhuo, Ying; Robins, Katherine J.; Fyans, Joanna K.; Herbert, Abigail J.; Law, Brian J. C.; Micklefield, Jason (25 November 2021). "Gene editing enables rapid engineering of complex antibiotic assembly lines". Nature Communications. 12 (1): 6872. doi:10.1038/s41467-021-27139-1. ISSN 2041-1723. PMC 8616955. PMID 34824225.
- ^ Winn, Michael; Rowlinson, Michael; Wang, Fanghua; Bering, Luis; Francis, Daniel; Levy, Colin; Micklefield, Jason (May 2021). "Discovery, characterization and engineering of ligases for amide synthesis". Nature. 593 (7859): 391–398. doi:10.1038/s41586-021-03447-w. ISSN 1476-4687.
- ^ Law, Brian J. C.; Zhuo, Ying; Winn, Michael; Francis, Daniel; Zhang, Yingxin; Samborskyy, Markiyan; Murphy, Annabel; Ren, Lujing; Leadlay, Peter F.; Micklefield, Jason (December 2018). "A vitamin K-dependent carboxylase orthologue is involved in antibiotic biosynthesis". Nature Catalysis. 1 (12): 977–984. doi:10.1038/s41929-018-0178-2. ISSN 2520-1158.
- ^ Craven, Elliott J.; Latham, Jonathan; Shepherd, Sarah A.; Khan, Imtiaz; Diaz-Rodriguez, Alba; Greaney, Michael F.; Micklefield, Jason (May 2021). "Programmable late-stage C−H bond functionalization enabled by integration of enzymes with chemocatalysis". Nature Catalysis. 4 (5): 385–394. doi:10.1038/s41929-021-00603-3. ISSN 2520-1158.
- ^ Bering, Luis; Craven, Elliott J.; Sowerby Thomas, Stanley A.; Shepherd, Sarah A.; Micklefield, Jason (19 January 2022). "Merging enzymes with chemocatalysis for amide bond synthesis". Nature Communications. 13 (1): 380. doi:10.1038/s41467-022-28005-4. ISSN 2041-1723. PMC 8770729. PMID 35046426.
- ^ Latham, Jonathan; Henry, Jean-Marc; Sharif, Humera H.; Menon, Binuraj R. K.; Shepherd, Sarah A.; Greaney, Michael F.; Micklefield, Jason (10 June 2016). "Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation". Nature Communications. 7 (1): 11873. doi:10.1038/ncomms11873. ISSN 2041-1723. PMC 4906404. PMID 27283121.