The Issaqueena Bombing Range was a World War II target range used for training flight crews from Greenville Army Air Base, later renamed Donaldson Air Force Base. The Army Air Field was established in 1942 for the preparation of aircrew using North American B-25 Mitchell twin-engine bombers, and a suitable target area was established using Lake Issaqueena, northwest of Calhoun, South Carolina and Clemson University, completely within the Clemson Experimental Forest. Bombing Range Road is still located off of State Highway S-39-291, southwest of Six Mile, South Carolina and west of Lake Issaqueena.