Analytical technique used to separate and identify ionized molecules in the gas phase
IMS chip at the U.S. Pacific Northwest National Laboratory: this dime-sized chip provides dozens of channels through which ions travel (perpendicular to plane of view) to be separated and identified
Ion mobility spectrometry (IMS) It is a method of conducting analytical research that separates and identifies ionized molecules present in the gas phase based on the mobility of the molecules in a carrier buffer gas. Even though it is used extensively for military or security objectives, such as detecting drugs and explosives, the technology also has many applications in laboratory analysis, including studying small and big biomolecules.[1] IMS instruments are extremely sensitive stand-alone devices, but are often coupled with mass spectrometry, gas chromatography or high-performance liquid chromatography in order to achieve a multi-dimensional separation. They come in various sizes, ranging from a few millimeters to several meters depending on the specific application, and are capable of operating under a broad range of conditions. IMS instruments such as microscale high-field asymmetric-waveform ion mobility spectrometry can be palm-portable for use in a range of applications including volatile organic compound (VOC) monitoring, biological sample analysis, medical diagnosis and food quality monitoring.[2] Systems operated at higher pressure (i.e. atmospheric conditions, 1 atm or 1013 hPa) are often accompanied by elevated temperature (above 100 °C), while lower pressure systems (1–20 hPa) do not require heating. [citation needed]
^Lanucara, F., Holman, S.W., Gray, C.J., and Eyers, C.E. (2014) The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics. Nature Chemistry 6:281-294.
^K.M.M. Kabir, W.A. Donald, Microscale differential ion mobility spectrometry for field deployable chemical analysis, TrAC Trends in Analytical Chemistry, DOI: https://doi.org/10.1016/j.trac.2017.10.011 (2017)
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