Ilaprazole information

Ilaprazole
Clinical data
Trade names	Noltec
Routes of; administration	Oral
ATC code	None;
Identifiers
	IUPAC name 2-[(RS)-[(4-methoxy-3-methylpyridin-2-yl)methyl]sulfinyl]-5-(1H-pyrrol-1-yl)-1H-benzimidazole;
CAS Number	172152-36-2;
PubChem CID	214351;
ChemSpider	185839;
UNII	776Q6XX45J;
ChEMBL	ChEMBL2106370;
Chemical and physical data
Formula	C19H18N4O2S
Molar mass	366.44 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1c(OC)ccnc1CS(=O)c2[nH]c3ccc(cc3n2)n4cccc4;
	InChI InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22); Key:HRRXCXABAPSOCP-UHFFFAOYSA-N;

Ilaprazole (trade name Noltec) is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD)^[1] and duodenal ulcer.^[2]^[3]

It is available in strengths of 5, 10, and 20 mg.

Clinical studies show that ilaprazole is at least as potent a PPI as omeprazole when taken in equivalent doses. Studies also showed that ilaprazole significantly prevented the development of reflux oesophagitis.

Ilaprazole is developed by Il-Yang Pharmaceutical (Korea), and is still under clinical trials with US FDA. It has launched in Korea and China for the treatment of gastric ulcer, duodenal ulcer, gastroesophageal reflux disease and erosive esophagitis.^[4]

Ilaprazole is sold in Mexico by Chinoin Pharmaceuticals under the brand name Norutec.^[5]

^ Savarino E, Ottonello A, Martinucci I, Dulbecco P, Savarino V (October 2016). "Ilaprazole for the treatment of gastro-esophageal reflux". Expert Opinion on Pharmacotherapy. 17 (15): 2107–13. doi:10.1080/14656566.2016.1232389. PMID 27598861. S2CID 38638311.
^ Bohidar NP, Krishna K, Panda BK, Patel C (2013). "Ilaprazole: Is this a superior proton pump inhibitor for duodenal ulcer?". Tropical Gastroenterology. 34 (2): 95–8. doi:10.7869/tg.2012.105. PMID 24377157.
^ Ji XQ, Du JF, Chen G, Chen G, Yu B (May 2014). "Efficacy of ilaprazole in the treatment of duodenal ulcers: a meta-analysis". World Journal of Gastroenterology. 20 (17): 5119–23. doi:10.3748/wjg.v20.i17.5119. PMC 4009550. PMID 24803828.
^ Clinical trial number NCT00952978 for "Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3)" at ClinicalTrials.gov
^ "Norutec". Chinoin Pharmaceuticals.

[Savarino_2016-1] Savarino E, Ottonello A, Martinucci I, Dulbecco P, Savarino V (October 2016). "Ilaprazole for the treatment of gastro-esophageal reflux". Expert Opinion on Pharmacotherapy. 17 (15): 2107–13. doi:10.1080/14656566.2016.1232389. PMID 27598861. S2CID 38638311.

[Bohidar_2013-2] Bohidar NP, Krishna K, Panda BK, Patel C (2013). "Ilaprazole: Is this a superior proton pump inhibitor for duodenal ulcer?". Tropical Gastroenterology. 34 (2): 95–8. doi:10.7869/tg.2012.105. PMID 24377157.

[Ji_2014-3] Ji XQ, Du JF, Chen G, Chen G, Yu B (May 2014). "Efficacy of ilaprazole in the treatment of duodenal ulcers: a meta-analysis". World Journal of Gastroenterology. 20 (17): 5119–23. doi:10.3748/wjg.v20.i17.5119. PMC 4009550. PMID 24803828.

[NCT00952978-4] Clinical trial number NCT00952978 for "Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3)" at ClinicalTrials.gov

[5] "Norutec". Chinoin Pharmaceuticals.

Ilaprazole information

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Ilaprazole

Benzimidazole

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Clinical data

Trade names	Noltec
Routes of administration	Oral
ATC code	None
Identifiers
IUPAC name 2-[(RS)-[(4-methoxy-3-methylpyridin-2-yl)methyl]sulfinyl]-5-(1H-pyrrol-1-yl)-1H-benzimidazole
CAS Number	172152-36-2
PubChem CID	214351
ChemSpider	185839
UNII	776Q6XX45J
ChEMBL	ChEMBL2106370
Chemical and physical data
Formula	C₁₉H₁₈N₄O₂S
Molar mass	366.44 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Cc1c(OC)ccnc1CS(=O)c2[nH]c3ccc(cc3n2)n4cccc4
InChI InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22) Key:HRRXCXABAPSOCP-UHFFFAOYSA-N