Global InformationIknife information
An onkoknife, iKnife, or intelligent scalpel is a surgical knife that tests tissue as it contacts it during an operation and immediately gives information as to whether that tissue contains cancer cells.[1] During a surgery this information is given continuously to the surgeon, significantly accelerating biological tissue analysis and enabling identification and removal of cancer cells. Electroknives have been in use since the 1920s and smart knife surgery is not limited only to cancer detection. In clinical studies the iKnife has shown impressive diagnostic accuracy - distinguishing benign ovarian tissue from cancerous tissue (97.4% sensitivity, 100% specificity),[2] breast tumour from normal breast tissue (90.9% sensitivity, 98.8% specificity)[3] and recognises histological features of poor prognostic outcome in colorectal carcinoma.[4] Furthermore, the technology behind iKnife - rapid evaporative ionisation mass spectrometry (REIMS) - can identify Candida yeasts down to species level.[5]
- ^ Balog, J; Sasi-Szabo, L; Kinross, J; Lewis, M. R; Muirhead, L. J; Veselkov, K; Mirnezami, R; Dezso, B; Damjanovich, L; Darzi, A; Nicholson, J. K; Takats, Z (2013). "Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry". Science Translational Medicine. 5 (194): 194ra93. doi:10.1126/scitranslmed.3005623. PMID 23863833. S2CID 206681695.
- ^ Phelps, David L; Balog, Júlia; Gildea, Louise F; Bodai, Zsolt; Savage, Adele; El-Bahrawy, Mona A; Speller, Abigail VM; Rosini, Francesca; Kudo, Hiromi (May 2018). "The surgical intelligent knife distinguishes normal, borderline and malignant gynaecological tissues using rapid evaporative ionisation mass spectrometry (REIMS)". British Journal of Cancer. 118 (10): 1349–1358. doi:10.1038/s41416-018-0048-3. ISSN 0007-0920. PMC 5959892. PMID 29670294.
- ^ St John, Edward R.; Balog, Julia; McKenzie, James S.; Rossi, Merja; Covington, April; Muirhead, Laura; Bodai, Zsolt; Rosini, Francesca; Speller, Abigail V. M. (December 2017). "Rapid evaporative ionisation mass spectrometry of electrosurgical vapours for the identification of breast pathology: towards an intelligent knife for breast cancer surgery". Breast Cancer Research. 19 (1): 59. doi:10.1186/s13058-017-0845-2. ISSN 1465-542X. PMC 5442854. PMID 28535818.
- ^ Alexander, James; Gildea, Louise; Balog, Julia; Speller, Abigail; McKenzie, James; Muirhead, Laura; Scott, Alasdair; Kontovounisios, Christos; Rasheed, Shanawaz (March 2017). "A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife". Surgical Endoscopy. 31 (3): 1361–1370. doi:10.1007/s00464-016-5121-5. ISSN 0930-2794. PMC 5315709. PMID 27501728.
- ^ Cameron, Simon J. S.; Bolt, Frances; Perdones-Montero, Alvaro; Rickards, Tony; Hardiman, Kate; Abdolrasouli, Alireza; Burke, Adam; Bodai, Zsolt; Karancsi, Tamas (December 2016). "Rapid Evaporative Ionisation Mass Spectrometry (REIMS) Provides Accurate Direct from Culture Species Identification within the Genus Candida". Scientific Reports. 6 (1): 36788. Bibcode:2016NatSR...636788C. doi:10.1038/srep36788. ISSN 2045-2322. PMC 5107957. PMID 27841356.