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HutP (Histidine utilizing Protein) is one of the anti-terminator proteins of Bacillus subtilis, which is responsible for regulating the expression of the hut structural genes of this organism in response to changes in the intracellular levels of L-histidine and divalent metal ions. In the hut operon, HutP is located just downstream from the promoter, while the five other subsequent structural genes, hutH, hutU, hutI, hutG and hutM, are positioned far downstream from the promoter. In the presence of L-histidine and divalent metal ions, HutP binds to the nascent hut mRNA leader transcript. This allows the anti-terminator to form, thereby preventing the formation of the terminator and permitting transcriptional read-through into the hut structural genes. In the absence of L-histidine and divalent metal ions or both, HutP does not bind to the hut mRNA, thus allowing the formation of a stem loop terminator structure within the nucleotide sequence located between the hutP and structural genes.
HutP is a 16.2 kDa protein consisting of 148 amino acid residues. HutP also exists in five other Bacillus species, including B. anthracis, B. cereus, B. halodurans, B. thuringiensis, and Geobacillus kautophilus, with 60% sequence identity. Thirumananseri Kumarevel solved the crystal structure of the HutP protein in the apo-form, binary complex (complexed with divalent metal ions or L-histidine), ternary complex (HutP-metal ions-L-histidine) and quaternary complexes (HutP-L-histidine-metal ions-RNA) and elegantly revealed the snapshots of metal-ion mediated anti-termination mechanism for the first time.
operon, HutP is located just downstream from the promoter, while the five other subsequent structural genes, hutH, hutU, hutI, hutG and hutM, are positioned...
Pizza Hut, LLC is an American multinational pizza restaurant chain and international franchise founded in 1958 in Wichita, Kansas by Dan and Frank Carney...
A Quonset hut /ˈkwɒnsɪt/ is a lightweight prefabricated structure of corrugated galvanized steel with a semi-circular cross-section. The design was developed...
Thomas Hutter is a fictional character in the silent expressionist horror film Nosferatu, eine Symphonie des Grauens (1922), its remake Nosferatu the Vampyre...
A Nissen hut is a prefabricated steel structure originally for military use, especially as barracks, made from a 210° portion of a cylindrical skin of...
1998 television advertisement for Pizza Hut. It was filmed in November 1997 on Red Square and in a Pizza Hut restaurant elsewhere in Moscow. It was aired...
Tropical Hut is a Filipino chain of fast food restaurants owned by Mercury Group of Companies, Inc. It is the 7th oldest food chain in the Philippines...
The Vallot Hut (French: Refuge Vallot) is a refuge in the Mont Blanc massif on the upper slopes of Mont Blanc in the Alps. It is located below the Bosses...
Hut 8 was a section in the Government Code and Cypher School (GC&CS) at Bletchley Park (the British World War II codebreaking station, located in Buckinghamshire)...
by his psychedelic experiences. Hutter was born in Vienna. With Jewish origins, the son of A. P. von Gütersloh, Hutter studied at the Academy of Fine Arts...
Leonhard Hutter (also Hütter, Latinized as Hutterus; 19 January 1563 – 23 October 1616) was a German Lutheran theologian. He was born at Nellingen near...
Hut 6 was a wartime section of the Government Code and Cypher School (GC&CS) at Bletchley Park, Buckinghamshire, Britain, tasked with the solution of...
A menstruation hut is a place of seclusion or isolation used by certain cultures with strong menstrual taboos. The same or a similar structure may be...
doi:10.1088/2041-8205/713/1/L41. S2CID 119120429. Zwart, S. F. P.; Baumgardt, H.; Hut, P.; et al. (2004). "Formation of massive black holes through runaway...
A beach hut (also known as a beach cabin, beach box or bathing box) is a small, usually wooden and often brightly coloured, box above the high tide mark...
The Jamesway hut is a portable and easy-to-assemble hut, designed for polar weather conditions. This version of the Quonset hut was created by James Manufacturing...
of the more noteworthy huts include Moscow Villa Hut, Valentine Hut, Seaman's Hut, and Mawsons Hut. In recent year, many huts have been lost through lack...
Piet Hut (born September 26, 1952) is a Dutch astrophysicist, who divides his time between research in computer simulations of dense stellar systems and...
The Charpoua Hut (French: Refuge de la Charpoua) is a refuge in the Mont Blanc massif in the Alps. Built in 1904 , it is located above the north bank...
The Cosmiques Hut (French: Refuge des Cosmiques) is a mountain hut in the Mont Blanc massif in the French Alps at an altitude of 3,613 m (11,854 ft). It...
The Gonella Hut (French: Refuge Francesco Gonella; Italian: Rifugio Francesco Gonella and sometimes called Rifugio del Dôme; or Refuge du Dôme) is a high...
Stone Hut is a small town in the Mid-north of South Australia, situated on the Horrocks Highway (section of Main North Road) midway between Laura and...
The Iris hut is a prefabricated steel structure used by the British military predominantly during the early part of the Second World War. They served...
Hut 7 was a wartime section of the Government Code and Cypher School (GC&CS) at Bletchley Park tasked with the solution of Japanese naval codes such as...
series of prefabricated huts to supplement the World-War-I-era Nissen hut. The Iris hut was one of these, a medium-scale hut of 35 feet (11 m) span and...
VC Recordings trading as Hut Records was a British record label brand which was started in 1990 as a wholly owned subsidiary of Virgin Records. Despite...
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