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Homofenazine information


For the current use of the Pasaden brand, see Etizolam.
Homofenazine
Clinical data
Trade namesPasaden,[1][2] Oldagen (in Argentina)[3][4]
Other namesHFZ[5]
ATC code
  • N05A
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)[6]
Identifiers
CAS Number
  • 3833-99-6 checkY
PubChem CID
  • 19687
ChemSpider
  • 18545 checkY
UNII
  • PEL7G6VRZ2
ChEBI
  • CHEBI:59071 checkY
ChEMBL
  • ChEMBL2105000 checkY
CompTox Dashboard (EPA)
  • DTXSID30191697 Edit this at Wikidata
Chemical and physical data
FormulaC23H28F3N3OS
Molar mass451.55 g·mol−1
3D model (JSmol)
  • Interactive image
Boiling point230–240 °C (446–464 °F) [7]
SMILES
  • C1CN(CCN(C1)CCO)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F
InChI
  • InChI=1S/C23H28F3N3OS/c24-23(25,26)18-7-8-22-20(17-18)29(19-5-1-2-6-21(19)31-22)12-4-11-27-9-3-10-28(14-13-27)15-16-30/h1-2,5-8,17,30H,3-4,9-16H2 checkY
  • Key:LOHNHQLZFYCAEQ-UHFFFAOYSA-N checkY

Homofenazine is an antipsychotic drug of the phenothiazines class.[5] It was synthesized by Wilhelm Schuler and colleagues at Degussa.[8][9] In 1966, it was released in Belgium under the brand name Pasaden.[1] At some point, it was quietly discontinued and is no longer marketed.[citation needed]

  1. ^ a b Schlesser JL (1990). 1991 Drugs available abroad: a guide to therapeutic drugs available and approved outside the U.S. Detroit : Gale Research. p. 107. ISBN 978-0-8103-7177-4. OCLC 1348900780.
  2. ^ "Substâncias e remédios sob controle" [Substances and drugs under control] (PDF). Jornal do Brasil (in Brazilian Portuguese). 1986-11-05. p. 14. Archived (PDF) from the original on 2023-08-08. Retrieved 2023-08-08.
  3. ^ Index Nominum 2000: International Drug Directory (17 ed.). Taylor & Francis. 2000. p. 1499. ISBN 9783887630751.
  4. ^ Sitting, Marshall (1988). Pharmaceutical Manufacturing Encyclopedia (Vols 1&2, 2nd Ed) (2 ed.). Westwood, NJ: Noyes Publications. p. 769. ISBN 0-8155-1144-2. LCCN 87-31547. OCLC 52233518.
  5. ^ a b Martindale: the complete drug reference. London; Chicago: Pharmaceutical Press. 2007. p. 899. ISBN 978-0-85369-687-2. OCLC 1176310249.
  6. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-03.
  7. ^ Elks J, Ganellin CR, eds. (1990). Dictionary of Drugs. Boston, MA: Springer US. p. 635. doi:10.1007/978-1-4757-2085-3. ISBN 978-1-4757-2087-7.
  8. ^ The Merck index : an encyclopedia of chemicals, drugs, and biologicals. Whitehouse Station, NJ : Merck. 1996. p. 810. ISBN 978-0-911910-12-4. OCLC 1285743402.
  9. ^ US patent 3040043, Schuler et al., "3-trifluoromethyl-10-[3'-(4"-(2"'-hydroxy ethyl)-homopiperazino)-propyl]-phenothiazine and 3-trifluoromethyl-10-[3'-(4"-(2"'-acetoxyethyl)-homopiperazino)-propyl]-phenothiazine", published 1962-06-19, issued 1962-06-19, assigned to Degussa .

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Homofenazine

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Homofenazine is an antipsychotic drug of the phenothiazines class. It was synthesized by Wilhelm Schuler and colleagues at Degussa. In 1966, it was released...

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Brazilian Controlled Drugs and Substances Act

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