The Holin superfamily II is a superfamily of putative pore-forming proteins. It is one of the seven different holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members. The Holin superfamily II includes the TC families:
1.E.1 - The P21 Holin S (P21 Holin) Family
1.E.6 - The T7 Holin (T7 Holin) Family
1.E.7 - The HP1 Holin (HP1 Holin) Family
1.E.25 - The Pseudomonas phage F116 Holin (F116 Holin) Family
1.E.50 - The Beta-Proteobacterial Holin (BP-Hol) Family
All four of these families are derived from Pseudomonadota and are of relatively small sizes, the average size of the proteins within the entire superfamily is 78 ± 14 amino acyl residues (aas). Some exceptions can be found (i.e., Lysis S family protein with 720 aas, TC# 1.E.1.1.7). As in holin superfamily I, proteins in these families generally exhibit of 2 transmembrane spanners (TMSs). Families 1 and 6 in Superfamily II are recognized domains in the Conserved Domains Database (CDD) as Lysis S and PHA00426 superfamilies, respectively, while families 7, and 25 lack recognized conserved domains.[1]
^Reddy, Bhaskara L.; Saier, Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. ISSN 0006-3002. PMC 3788059. PMID 23856191.
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