Harlequin color change is a cutaneous condition seen in newborn babies characterized by momentary red color changes of half the child, sharply demarcated at the body's midline. This transient change occurs in approximately 10% of healthy newborns.[1] It is seen usually between two and five days of birth. The condition lasts from 30 seconds to 20 minutes and then fades. It may recur when the infant is placed on their side, as the intensity of color has been shown to be gravity dependent and considerably variable from one infant to another.[2]
The dark red color skin of the newborn with harlequin signs indicates polycythemia. Polycythemia is common in preterm infants because of the presence of fetal red blood cells (RBCs).[3] The condition is also often seen in healthy newborns although associations like with prematurity, low birth weight, hypoxia, systemic use of prostaglandin E1, or intracranial injury, meningitis and anesthesia have been mentioned in the literature.[4][5][6][7][8][9] Probable differential diagnosis are Port-wine stain and nascent hemangioma of infancy, but these can be differentiated due to transient nature of this condition.[1]
Hypothesized pathogenesis involves temporary imbalance in the tone of cutaneous blood vessels secondary to hypothalamic immaturity.[10]
This condition was first described by Neligan and Strang in 1952 and was named so.[5]
^ abCordoro, Kelly M.; Speetzen, Larisa S.; Koerper, Marion A.; Frieden, Ilona J. "Physiologic changes in vascular birthmarks during early infancy: Mechanisms and clinical implications". Journal of the American Academy of Dermatology. 60 (4): 669–675. doi:10.1016/j.jaad.2008.11.020.
^M.A. Selimoglu et al., "PICTURE OF THE MONTH - HARLEQUIN COLOR-CHANGE", Archives of Pediatrics & Adolescent Medicine, 149(10), 1995, pp. 1171-1172
^{Perry, S. E., Hockenberry, M. J., Lowdermilk, D. L., & Wilson, D. (n.d.). Maternal child nursing care.}
^Velayuthan, S.; Sankararaman, S. (1 July 2013). "Visual Diagnosis: Newborn Who Has Unilateral Color Change". Pediatrics in Review. 34 (7): e25–e26. doi:10.1542/pir.34-7-e25.
^ abNeligan GA, Strang LB (1952). "A "harlequin" colour change in the newborn". Lancet. 263: 1005–1007. doi:10.1016/s0140-6736(52)91182-3.
^Rao, Jaggi; Campbell, Morag E.; Krol, Alfons (1 September 2004). "The Harlequin Color Change and Association with Prostaglandin E1". Pediatric Dermatology. 21 (5): 573–576. doi:10.1111/j.0736-8046.2004.21511.x.
^Wagner, DL; Sewell, AD (May 1985). "Harlequin color change in an infant during anesthesia" (PDF). Anesthesiology. 62 (5): 695. doi:10.1097/00000542-198505000-00039. PMID 4039544.
^Lee, RS; Wan, HS; Chan, RL (December 2012). "Harlequin colour change in a newborn with meningitis". Hong Kong medical journal. 18 (6): 539.e3-4. PMID 23223664.
^Rao, Jaggi; Krol, Alfons (4 September 2003). "The Harlequin Color Change". New England Journal of Medicine. 349 (10): 968–968. doi:10.1056/NEJMicm020831.
^PADDA, GURPREET S.; CRUZ, OSCAR A.; SILEN, MARK L.; KROCK, JEREMY L. (1 March 1999). "Skin conductance responses in paediatric Harlequin syndrome". Pediatric Anesthesia. 9 (2): 159–162. doi:10.1046/j.1460-9592.1999.9220266.x.
and 23 Related for: Harlequin color change information
Harlequincolorchange is a cutaneous condition seen in newborn babies characterized by momentary red colorchanges of half the child, sharply demarcated...
HarlequinColor may refer to: Harlequin (color), a color located between green and yellow ChromaFlair, a pigment used in paint systems, primarily for automobiles...
The Harlequin is a colourful breed of rabbit originating from France. It is a breed based around the coloration and markings, rather than fur and body...
green on the RGB color wheel. The first recorded use of harlequin as a color name in English was in 1923. Harlequin is a pure spectral color at approximately...
a color variation known as "golden", popular in the UK, which replaces the black feather pigments with a light golden brown color. Welsh Harlequins have...
The harlequin cabbage bug (Murgantia histrionica), also known as calico bug, fire bug or harlequin bug, is a black stinkbug of the family Pentatomidae...
dermatitis of Gougerot and Blum) Granulomatosis with polyangiitis Harlequincolorchange Hematopoietic ulcer Hennekam syndrome (Hennekam lymphangiectasia-lymphedema...
The harlequin fish (Othos dentex) is a species of marine ray-finned fish in the subfamily Anthiinae, part of the family Serranidae, the groupers and sea...
earlier Volkswagen Polo Harlequin special edition, the Golf Harlequins were created in four variations, by taking four solid color models and interchanging...
and white) h = Non-harlequin (if M/-, normal expression of merle) H/h heterozygotes are harlequin and h/h homozygotes are non-harlequin. Breeding data suggests...
synonymously with predecessors like jester, buffoon, joker, fool, or harlequin. Clowns have a diverse tradition with significant variations in costume...
name of a rabbit's color/pattern (or fur type). For example, Harlequin is the name of a breed whose color/pattern is known as harlequin. (This arose from...
Stephens was an editor for Harlequin, Dell (Candlelight Romances), and Bantam. She also established Women Writers of Color, an organization aiming to...
SS)=low degree of spotting white (between 50 and 100% white); dominant harlequin and van pattern. The van pattern is named after the Lake Van region in...
harlequin and mantle Black: The colour is a glossy black. White markings on the chest and toes are not desirable and considered faults. Harlequin: The...
"Hanahaki Disease". Fanlore. September 21, 2017. Retrieved January 15, 2018. "Harlequin ichthyosis | Genetic and Rare Diseases Information Center (GARD) – an...
be changed by any of the genes which usually affect them. Eumelanin (the pigment making up the stripes) can be affected by: merle (and harlequin), liver...
French-bred pink to blue mophead 'Hamburg'; deep-colored pink to blue mophead 'Harlequin'; a picoteed pink to purple mophead 'Lady in Red'; large lacecap flowers...
novels for women in the 1930s. Their books were sold in North America by Harlequin Enterprises Ltd, which began direct marketing to readers and allowing...
and deadgrass are used to describe the desired Chesapeake Bay Retriever color that resembles "that of its working surroundings" as closely as possible...
The Guajira stubfoot toad or Carrikeri harlequin frog (Atelopus carrikeri) is a species of toad in the family Bufonidae. It is about 5 cm (2.0 in) long...