George Washington University (BA, 1933), Johns Hopkins University (PhD 1936)
Known for
Double-reciprocal plot
Children
11 great-greatgrandchildren at the time of his death[1]
Scientific career
Fields
Biochemistry
Institutions
U.S. Department of Agriculture, Western Regional Research Center, Albany, California
Hans Lineweaver (December 25, 1907 – June 10, 2009) was an American physical chemist, who is credited with introducing the double-reciprocal plot or Lineweaver–Burk plot.[2] The paper containing the equation was co-authored by Dean Burk, and was entitled "The Determination of Enzyme Dissociation Constants (1934)". It remains the most frequently cited paper[3] to appear in the Journal of the American Chemical Society.[4] Lineweaver and Burk collaborated with the eminent statistician W. Edwards Deming on the statistical analysis of their data:[5] they used the plot for illustrating the results, not for the analysis itself.
Linearizations of the Henri-Michaelis-Menten law of enzyme kinetics [6][7] were important in the era before general availability of computers to determine the parameters Vmax and Km from experimental data, even though there are significant statistical problems involved in this procedure.[8][9] These are still used for data presentation. All three possible methods of linearization (now often called Lineweaver-Burk, Eadie-Hofstee and Hanes plots, respectively) were originally proposed by Barnet Woolf, who was unable to formally publish them due to injuries received in a car accident. However, he had discussed them with his close friend and fellow member of the British Communist Party, J. B. S. Haldane, who referred to them in his seminal book on enzyme kinetics.[10] However, the linearizations were largely ignored until they were re-invented by the authors whose name they now bear.[11]
Lineweaver developed the Lineweaver–Burk equation in 1934 while still a graduate student, working as a laboratory assistant under Burk at the U.S. Department of Agriculture in Washington, D.C. He was an internationally recognized authority on food technology as applied to the processing, preservation and safety of poultry and eggs.
^ abcCite error: The named reference fek was invoked but never defined (see the help page).
^The credit is misleading, as all three linearizations of the Michaelis–Menten equation were proposed by Barnet Woolf and first published by J. B. S. Haldane: see below.
^Almost 14000 citations by March 2023.
^Lineweaver, H; Burk, D. (1934). "The Determination of Enzyme Dissociation Constants". Journal of the American Chemical Society. 56 (3): 658–666. doi:10.1021/ja01318a036.
^Lineweaver H, Burk D, Deming, W E (1934). "The dissociation constant of nitrogen-nitrogenase in Azobacter". Journal of the American Chemical Society. 56: 225–230. doi:10.1021/ja01316a071.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Henri, Victor (1902). "Theorie generale de l'action de quelques diastases". Compt. Rend. Acad. Sci. Paris. 135: 916–919.
^Michaelis, L.; Menten, M.L. (1913). "Die Kinetik der Invertin-Wirkung". Biochem. Z. 49: 333–369.
^Wilkinson, G.N. (1961). "Statistical estimation in enzyme kinetics". Biochem. J. 80 (2): 324–332. doi:10.1042/bj0800324. PMC 1244002. PMID 13785321.
^Johansen G, Lowry R (1961). "Statistical analysis of enzymic steady-state rate data". Comptes rendus des travaux du Laboratoire Carlsberg. 32: 185–214. PMID 14451942.
HansLineweaver (December 25, 1907 – June 10, 2009) was an American physical chemist, who is credited with introducing the double-reciprocal plot or Lineweaver–Burk...
Cancer Institute. In 1934, he developed the Lineweaver–Burk plot together with HansLineweaver. Lineweaver and Burk collaborated with the eminent statistician...
Research Laboratory, co-discoverer of biotin. He is credited (with HansLineweaver) with introducing the double-reciprocal plot in kinetics. He became...
Society for the Systems Sciences HansLineweaver (B.A. 1930, M.A. 1933), physical chemist who developed the Lineweaver–Burk plot Marcus Ward Lyon Jr.,...
Stewart 1968–69: Bernard L. Oser 1969–70: Herbert E. Robinson 1970–71: HansLineweaver 1971–72: Richard L. Hall 1972–73: Ben F. Buchanan 1973–74: Reid T....
Interscience Publishers. p. 391. ISBN 978-0-470-51381-1. Egan, Chas A.; Lineweaver, Charles H. (2010). "A Larger Estimate of the Entropy of the Universe"...
PMC 6099700. PMID 30158736. Sagan (1979), p. 62. Kiely et al. (2019), p. 1475. Lineweaver (2022) Tressoldi, p. 1. Voss et al. (2014), p. 893. Smith (2011) Tressoldi...
"approach" are redshifted. For more on this bizarre result see: Davis, T. M.; Lineweaver, C. H.; Webb, J. K. (April 2003). "Solutions to the tethered galaxy problem...
Archived from the original on 19 October 2023. Retrieved 19 October 2023. Lineweaver, Charles H.; Patel, Vihan N. (1 October 2023). "All objects and some questions"...
Retrieved 22 February 2019. Davies, P. C. W.; Benner, S.A.; Cleland, C.E.; Lineweaver, C.H.; McKay, C.P.; Wolfe-Simon, F. (2009). "Signatures of a Shadow Biosphere"...
arXiv:astro-ph/0702510. Bibcode:2007ApJ...655..144M. doi:10.1086/509598. S2CID 16483538. Lineweaver, Charles H.; Davis, Tamara M. (1 March 2005). "Misconceptions about the...
Bibcode:2010A&A...513A..49S. doi:10.1051/0004-6361/200911862. S2CID 5688996. Lineweaver, Charles H. (2000). "An estimate of the age distribution of terrestrial...
is sometimes referred to as the "algae vs. alumnae" problem. Charles Lineweaver states that when considering any extreme trait in an animal, intermediate...
Cambridge university press. ISBN 978-1-107-19789-3. Davis, Tamara M.; Lineweaver, Charles H. (2004). "Expanding Confusion: Common Misconceptions of Cosmological...
Bibcode:1983coex....1....3I. Zeilik & Gregory 1998, p. 207. Charles H. Lineweaver (2001). "An Estimate of the Age Distribution of Terrestrial Planets in...
Sciences," in Complexity and the Arrow of Time: What is Complexity?, Lineweaver, Davies and Ruse (eds.), Cambridge Univ. Press, 2013. Spier, F., Big History...
in Theory of the Earth, pp. 147–175 ISBN 0865421234 Wang, Haiyang S.; Lineweaver, Charles H.; Ireland, Trevor R. (2018-01-01). "The elemental abundances...
original on 12 November 2007. Retrieved 30 April 2022. Robles, José A.; Lineweaver, Charles H.; Grether, Daniel; Flynn, Chris; Egan, Chas A.; Pracy, Michael...
entropy production) Biogeochemistry Problems". In Dewar, Roderick C.; Lineweaver, Charles H.; Niven, Robert K.; Regenauer-Lieb, Klaus (eds.). Beyond the...
Education Support Network concluded in September, 2009." Davis, Tamara M.; Lineweaver, Charles H. (31 March 2004). "Expanding Confusion: Common Misconceptions...
Bibcode:2007ApJ...664.1154S. doi:10.1086/519231. S2CID 15144741. Grether, Daniel; Lineweaver, Charles H. (2006-04-01). "How Dry is the Brown Dwarf Desert? Quantifying...
in Spider-Man, Babette in Arcane), (d. 2021). September 8: Stephen J. Lineweaver, American production designer, art director and visual consultant (The...
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