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Haloacid dehydrogenase superfamily information


Hydrolase_3
crystal structure of had-like phosphatase yida from e. coli
Identifiers
SymbolHydrolase_3
PfamPF08282
Pfam clanCL0137
InterProIPR013200
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The haloacid dehydrogenase superfamily (HAD superfamily) is a superfamily of enzymes that include phosphatases, phosphonatases, P-type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, and are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification.[1]

  1. ^ Koonin EV, Tatusov RL (November 1994). "Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search". Journal of Molecular Biology. 244 (1): 125–32. doi:10.1006/jmbi.1994.1711. PMID 7966317.

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Haloacid dehydrogenase superfamily

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The haloacid dehydrogenase superfamily (HAD superfamily) is a superfamily of enzymes that include phosphatases, phosphonatases, P-type ATPases, beta-phosphoglucomutases...

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Enzyme Function Initiative

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epimerization/racemization or β-elimination of carboxylate substrates. The Haloacid dehydrogenase superfamily contains evolutionarily related enzymes with a Rossmanoid...

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Protein phosphatase

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to DNA damage to prevent chromosomal abnormalities. The haloacid dehalogenase (HAD) superfamily is a further PP group that uses Asp as a nucleophile and...

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