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HKA test information


The HKA Test, named after Richard R. Hudson, Martin Kreitman, and Montserrat Aguadé, is a statistical test used in genetics to evaluate the predictions of the Neutral Theory of molecular evolution. By comparing the polymorphism within each species and the divergence observed between two species at two or more loci, the test can determine whether the observed difference is likely due to neutral evolution or rather due to adaptive evolution.[1] Developed in 1987, the HKA test is a precursor to the McDonald-Kreitman test, which was derived in 1991. The HKA test is best used to look for balancing selection, recent selective sweeps or other variation-reducing forces.[2]

  1. ^ Hudson, RR; Kreitman, M; Aguadé, M (May 1987). "A test of neutral molecular evolution based on nucleotide data". Genetics. 116 (1): 153–9. doi:10.1093/genetics/116.1.153. PMC 1203113. PMID 3110004.
  2. ^ Kreitman, Martin (1 September 2000). "Methods to Detect Selection in Populations with Applications to the Human". Annual Review of Genomics and Human Genetics. 1 (1): 539–559. doi:10.1146/annurev.genom.1.1.539. PMID 11701640.

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