Human protein-coding gene
H3C14 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IIJ, 2X4W, 2X4X, 2X4Y, 3AV1, 3DB3, 3MO8, 3R93, 4MZF, 4MZG, 4MZH, 4OUC, 5BO0, 2HIO, 5B0Z, 2ARO, 1EQZ, 1HQ3, 4KGC, 1TZY, 4UUZ, 2F8N, 5B0Y, 4LD9, 5B40, 5CIU
Identifiers Aliases H3C14 , H3, H3.2, H3/M, H3F2, H3FM, H3FN, histone cluster 2, H3c, histone cluster 2 H3 family member c, HIST2H3C, H3 clustered histone 14, H3C15, H3C13External IDs OMIM: 142780; MGI: 3650546; HomoloGene: 134475; GeneCards: H3C14; OMA:H3C14 - orthologs Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 149,840,687 bp[1] End 149,841,208 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells epithelium of colon ganglionic eminence ventricular zone right uterine tube cerebellum cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum gonad
More reference expression data
BioGPS
Gene ontology Molecular function
protein heterodimerization activity
DNA binding
histone binding
protein binding
chromatin binding
nucleosomal DNA binding
Cellular component
extracellular exosome
extracellular region
nucleoplasm
chromosome
nucleosome
nucleus
chromatin
Biological process
epigenetic maintenance of chromatin in transcription-competent conformation
blood coagulation
rDNA heterochromatin assembly
nucleosome assembly
negative regulation of gene expression, epigenetic
negative regulation of transcription by RNA polymerase II
chromatin organization
regulation of gene silencing by miRNA
interleukin-7-mediated signaling pathway
regulation of megakaryocyte differentiation
regulation of hematopoietic stem cell differentiation
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 1: 149.84 – 149.84 Mb n/a PubMed search [2] [3]
Wikidata View/Edit Human View/Edit Mouse
Histone H3.2 is a protein that in humans is encoded by the HIST2H3C gene.[4] [5] [6]
^ a b c GRCh38: Ensembl release 89: ENSG00000203811 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics . 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ Marashi F, Helms S, Shiels A, Silverstein S, Greenspan DS, Stein G, Stein J (Jul 1986). "Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences". Biochem Cell Biol . 64 (4): 277–289. doi:10.1139/o86-039. PMID 3013246.
^ "Entrez Gene: HIST2H3C histone cluster 2, H3c".
Last Update: 2023-12-23T18:08:21Z
Histone H3.2 is a protein that in humans is encoded by the HIST2H3C gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure...
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Last Update: 2024-04-22T18:41:09Z
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