HARS information

HARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X59, 2LW7, 4G84, 4G85, 4PHC, 4X5O
Identifiers
Aliases	HARS1, HRS, USH3B, CMT2W, histidyl-tRNA synthetase, HARS, histidyl-tRNA synthetase 1
External IDs	OMIM: 142810; MGI: 108087; HomoloGene: 1592; GeneCards: HARS1; OMA:HARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,691,537 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,916,258 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; right frontal lobe; ; anterior pituitary; ; Pars compacta; ; pars reticulata; ; right hemisphere of cerebellum; ; Brodmann area 9; ; nucleus accumbens; ; putamen; ; caudate nucleus;
	Top expressed in
	ureter; ; cingulate gyrus; ; primitive streak; ; fetal liver hematopoietic progenitor cell; ; medial vestibular nucleus; ; medullary collecting duct; ; lateral hypothalamus; ; epiblast; ; medial dorsal nucleus; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; ATP binding; histidine-tRNA ligase activity; identical protein binding;
Cellular component	cytoplasm; mitochondrion; cytosol;
Biological process	tRNA aminoacylation for protein translation; protein biosynthesis; mitochondrial translation; histidyl-tRNA aminoacylation;
	Sources:Amigo / QuickGO
Orthologs
	3035
	15115
	ENSG00000170445
	ENSMUSG00000001380
	P12081
	Q61035
NM_002109; NM_001258040; NM_001258041; NM_001258042; NM_001289092;
	NM_001289093; NM_001289094
	NM_008214
NP_001244969; NP_001244970; NP_001244971; NP_001276021; NP_001276022;
	NP_001276023; NP_002100
	NP_032240
	Wikidata
View/Edit Human	View/Edit Mouse

Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170445 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001380 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: HARS histidyl-tRNA synthetase".
^ Wasmuth JJ, Carlock LR (1986). "Chromosomal localization of human gene for histidyl-tRNA synthetase: clustering of genes encoding aminoacyl-tRNA synthetases on human chromosome 5". Somat. Cell Mol. Genet. 12 (5): 513–7. doi:10.1007/BF01539922. PMID 3464104. S2CID 28520231.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170445 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001380 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HARS histidyl-tRNA synthetase".

[pmid3464104-6] Wasmuth JJ, Carlock LR (1986). "Chromosomal localization of human gene for histidyl-tRNA synthetase: clustering of genes encoding aminoacyl-tRNA synthetases on human chromosome 5". Somat. Cell Mol. Genet. 12 (5): 513–7. doi:10.1007/BF01539922. PMID 3464104. S2CID 28520231.

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