Structure of gurmarin, a sweet taste-suppressing polypeptide.[1]
Identifiers
Symbol
Gurmarin
Pfam
PF11410
InterPro
IPR010485
SCOP2
1gur / SCOPe / SUPFAM
OPM superfamily
112
OPM protein
1c4e
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Gurmarin
Identifiers
Organism
Gymnema sylvestre
Symbol
?
PDB
1c4e
UniProt
P25810
Search for
Structures
Swiss-model
Domains
InterPro
3D Structure of Gurmarin[2]
Gurmarin is a 35-residue polypeptide from the Asclepiad vine Gymnema sylvestre (Gurmar). It has been utilized as a pharmacological tool in the study of sweet-taste transduction because of its ability to selectively inhibit the neural response to sweet taste in rats.[1] This rat inhibition appears to have high specificity to sugar (sweetener) molecules like sucrose, glucose, and saccharin as well as the amino acid glycine.[3] As a sweet-taste-suppressing protein, Gurmarin shows signs of being reversible in nature although having little to no effect on the sweet taste sensation in humans suggesting the protein is only active on rodent sweet taste receptors.[4]
^ abArai K, Ishima R, Morikawa S, Miyasaka A, Imoto T, Yoshimura S, et al. (April 1995). "Three-dimensional structure of gurmarin, a sweet taste-suppressing polypeptide". Journal of Biomolecular NMR. 5 (3): 297–305. doi:10.1007/BF00211756. PMID 7787425. S2CID 36794097.
^"Crystal structure of gurmarin, a sweet taste suppressing polypeptide". RCSB Protein Data Bank. 5OLL. Retrieved 2023-11-28.
^"Gurmarin GUR_GYMSY". Uniprot.org. May 1, 1992. P25810. Retrieved May 16, 2022.
^Sigoillot M, Brockhoff A, Meyerhof W, Briand L (November 2012). "Sweet-taste-suppressing compounds: current knowledge and perspectives of application". Applied Microbiology and Biotechnology. 96 (3): 619–630. doi:10.1007/s00253-012-4387-3. PMID 22983596.
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