This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "GnRH2" – news · newspapers · books · scholar · JSTOR(June 2011) (Learn how and when to remove this message)
GnRH2
Identifiers
Aliases
Gonadotropin-releasing hormone II
External IDs
GeneCards: [1]; OMA:- orthologs
Orthologs
Species
Human
Mouse
Entrez
n/a
n/a
Ensembl
n/a
n/a
UniProt
n a
n/a
RefSeq (mRNA)
n/a
n/a
RefSeq (protein)
n/a
n/a
Location (UCSC)
n/a
n/a
PubMed search
n/a
n/a
Wikidata
View/Edit Human
GnRH2, also known as gonadotropin-releasing hormone II or LHRH-II. Its gene is located on human chromosome 20.[1]
Most vertebrate species possess two or three forms of gonadotropin-releasing hormone (GnRH) expressed in three distinct brain regions. Although the function of the hypothalamic form (GnRH1; common to many vertebrates), in controlling the reproductive axis has been defined, the functions of the other two isoforms (GnRH2 and GnRH3) remain largely unknown.[2] The presence and conservation of GnRH2 across vertebrate species indicate important biological roles, but the absence of GnRH2 in rodents has greatly hampered the use of these vertebrate models and modern molecular tools to pursue its functions.[3]
A relatively well-documented function of GnRH2 is that the administration of GnRH2 has anorexigenic effects in female musk shrew,[4] mouse,[5] goldfish [6] and zebrafish,[7] but the mechanisms are still unclear.
^EntrezGene 2797
^The Highly Conserved Gonadotropin-Releasing Hormone-2 Form Acts as a Melatonin-Releasing Factor in the Pineal of a Teleost Fish, the European Sea Bass Dicentrarchus labrax[permanent dead link]
^Comprehensive Analysis of GnRH2 Neuronal Projections in Zebrafish
^Kauffman AS, Rissman EF (February 2004). "The evolutionarily conserved gonadotropin-releasing hormone II modifies food intake". Endocrinology. 145 (2): 686–691. doi:10.1210/en.2003-1150. PMID 14576176.
^Kauffman AS, Rissman EF (August 2004). "A critical role for the evolutionarily conserved gonadotropin-releasing hormone II: mediation of energy status and female sexual behavior". Endocrinology. 145 (8): 3639–3646. doi:10.1210/en.2004-0148. PMID 15105381.
^Matsuda K, Nakamura K, Shimakura S, Miura T, Kageyama H, Uchiyama M, et al. (June 2008). "Inhibitory effect of chicken gonadotropin-releasing hormone II on food intake in the goldfish, Carassius auratus". Hormones and Behavior. 54 (1): 83–89. doi:10.1016/j.yhbeh.2008.01.011. PMID 18342861. S2CID 23262968.
^Gonadotropin-releasing hormone 2 suppresses food intake in the zebrafish, Danio rerio
functions of the other two isoforms (GnRH2 and GnRH3) remain largely unknown. The presence and conservation of GnRH2 across vertebrate species indicate...
Progonadoliberin-2 is a protein that in humans is encoded by the GNRH2 gene. The protein encoded by this gene is a preproprotein that is cleaved to form...
gonadotropin-releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane...
vertebrates typically have four cone opsin classes (LWS, SWS1, SWS2, and Rh2) as well as one rod opsin class (rhodopsin, Rh1), all of which were inherited...
(λmax). Vertebrates generally have four (SWS1, SWS2, RH2, LWS) classes of photopsins. Mammals lost Rh2 and SWS2 classes during the nocturnal bottleneck,...